Ward, Heather A. and Murphy, Neil and Weiderpass, Elisabete and Leitzmann, Michael F. and Aglago, Elom and Gunter, Marc J. and Freisling, Heinz and Jenab, Mazda and Boutron-Ruault, Marie-Christine and Severi, Gianluca and Carbonnel, Franck and Kuehn, Tilman and Kaaks, Rudolf and Boeing, Heiner and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Merino, Susana and Zamora-Ros, Raul and Rodriguez-Barranco, Miguel and Dorronsoro, Miren and Chirlaque, Maria-Dolores and Barricarte, Aurelio and Perez-Cornago, Aurora and Trichopoulou, Antonia and Bamia, Christina and Lagiou, Pagona and Masala, Giovanna and Grioni, Sara and Tumino, Rosario and Sacerdote, Carlotta and Mattiello, Amalia and Bueno-de-Mesquita, Bas and Vermeulen, Roel and Van Gils, Carla and Nystrom, Hanna and Rutegard, Martin and Aune, Dagfinn and Riboli, Elio and Cross, Amanda J. (2019) Gallstones and incident colorectal cancer in a large pan-European cohort study. INTERNATIONAL JOURNAL OF CANCER, 145 (6). pp. 1510-1516. ISSN 0020-7136, 1097-0215
Full text not available from this repository. (Request a copy)Abstract
Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclear whether gallstones are a risk factor for CRC. We examined the association between history of gallstones and CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a prospective cohort of over half a million participants from ten European countries. History of gallstones was assessed at baseline using a self-reported questionnaire. The analytic cohort included 334,986 participants; a history of gallstones was reported by 3,917 men and 19,836 women, and incident CRC was diagnosed among 1,832 men and 2,178 women (mean follow-up: 13.6 years). Hazard ratios (HR) and 95% confidence intervals (CI) for the association between gallstones and CRC were estimated using Cox proportional hazards regression models, stratified by sex, study centre and age at recruitment. The models were adjusted for body mass index, diabetes, alcohol intake and physical activity. A positive, marginally significant association was detected between gallstones and CRC among women in multivariable analyses (HR = 1.14, 95%CI 0.99-1.31, p = 0.077). The relationship between gallstones and CRC among men was inverse but not significant (HR = 0.81, 95%CI 0.63-1.04, p = 0.10). Additional adjustment for details of reproductive history or waist circumference yielded minimal changes to the observed associations. Further research is required to confirm the nature of the association between gallstones and CRC by sex.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SERUM BILIRUBIN; RISK; CHOLECYSTECTOMY; ASSOCIATION; POPULATION; DISEASE; Gallstones; colorectal cancer; EPIC; cohort |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Mar 2020 06:03 |
| Last Modified: | 31 Mar 2020 06:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26250 |
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