Steinwachs, Matthias R. and Gille, Justus and Volz, Martin and Anders, Sven and Jakob, Roland and De Girolamo, Laura and Volpi, Piero and Schiavone-Panni, Alfredo and Scheffler, Sven and Reiss, Eric and Wittmann, Udo (2019) Systematic Review and Meta-Analysis of the Clinical Evidence on the Use of Autologous Matrix-Induced Chondrogenesis in the Knee. CARTILAGE: UNSP 19476. ISSN 1947-6035, 1947-6043
Full text not available from this repository. (Request a copy)Abstract
Objective A systematic review and meta-analysis of Autologous Matrix-Induced Chondrogenesis (AMIC (R)) outcomes for grade III/IV chondral and osteochondral lesions of the knee treated with Chondro-Gide (R). Design Studies with a minimum follow-up of 1 year providing clinical results of AMIC repair in the knee were included based on PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Methodological quality was assessed by the modified Coleman Methodology Score (mCMS). The meta-analysis was comparing pain VAS (Visual Analog Scale), Lysholm score, and IKDC score (International Knee Documentation Committee) between baseline and follow-up after 1 or 2 years and after >3 years. Results Twelve studies (375 patients) were included. The mCMS demonstrated a suboptimal study design (ranking between 52 and 80). The mean age was 36.2 years (14-70 years). The mean defect size was 4.24 cm(2) (0.8-22 cm(2)). The results from the random effects model indicated a clinically significant (P < 0.05) improvement of pain VAS from baseline to follow-up at year 1 to 2 of -4.02(confidence interval -4.37; -3.67), still significant after 3 years. Lysholm score at year 1 or 2 improved significantly and remained highly significant after 3 years. IKDC score showed highly significant improvement of 32.61 between 1 and 2 years versus baseline values maintained after 3 years. Conclusions The AMIC procedure significantly improved the clinical status and functional scoring versus preoperative values. Evidence was obtained in a non-selected patient population, corresponding to real-life treatment of knee chondral and osteochondral defects. The evidence is sufficient to recommend AMIC in this indication.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARTICULAR-CARTILAGE DEFECTS; BONE-MARROW STIMULATION; MICROFRACTURE TECHNIQUE; CHONDRAL DEFECTS; REPAIR; FAILURE; SURGERY; autologous matrix-induced chondrogenesis (AMIC (R)); microfracture; Chondro-Gide (R); cartilage; knee |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 06 Apr 2020 08:36 |
| Last Modified: | 06 Apr 2020 08:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26264 |
Actions (login required)
 |
View Item |
