Rosenkranz, Stephan and Diller, Gerhard-Paul and Dumitrescu, Daniel and Ewer, Ralf and Ghofrani, H. Ardeschir and Gruenig, Ekkehard and Halank, Michael and Held, Matthias and Kaemmerer, Harald and Klose, Hans and Kovacs, Gabor and Konstantinides, Stavros and Lang, Irene M. and Lange, Tobias J. and Leuchte, Hanno and Mayer, Eckhard and Olschewski, Andrea and Olschewski, Horst and Olsson, Karen M. and Opitz, Christian and Schermuly, Ralph T. and Seeger, Werner and Wilkens, Heinrike and Hoeper, Marius M. (2019) Hemodynamic Definition of Pulmonary Hypertension: Commentary on the Proposed Change by the 6th World Symposium on Pulmonary Hypertension. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 144 (19). pp. 1367-1372. ISSN 0012-0472, 1439-4413
Full text not available from this repository. (Request a copy)Abstract
The ESC/ERS guidelines (published at the end of 2015) and other international recommendations defined pulmonary hypertension (PH) by an invasively measured mean pulmonary arterial pressure (mPAP) >= 25mmHg at rest. At the 6th World Symposium on Pulmonary Hypertension in Nice a modification of this hemodynamic definition in the sense of lowering the threshold to >20mmHg was proposed. A pulmonary vascular resistance (PVR) >= 3 Wood units (WU) is additionally required for the diagnosis of pre-capillary PH. This modification must be critically reviewed with regard to the underlying rationale and possible consequences. Therefore, a detailed explanation is required. In particular, it must be made clear that this change currently has no influence on the evidence-based and approval-compliant prescription of drugs for the targeted therapy of pulmonary arterial hypertension (PAH).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SYSTEMIC-SCLEROSIS; ARTERIAL-PRESSURE; DIAGNOSIS; MORTALITY; pulmonary hypertension; prognosis; hemodynamic definition |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2020 13:35 |
| Last Modified: | 30 Mar 2020 13:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26298 |
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