Gabes, M. and Chamlin, S. L. and Lai, J-S and Cella, D. and Mancini, A. J. and Apfelbacher, C. J. (2020) Evaluation of responsiveness and estimation of smallest detectable change and minimal important change scores for the Childhood Atopic Dermatitis Impact Scale. BRITISH JOURNAL OF DERMATOLOGY, 182 (2). pp. 348-354. ISSN 0007-0963, 1365-2133
Full text not available from this repository. (Request a copy)Abstract
Background The Childhood Atopic Dermatitis Impact Scale (CADIS) is an instrument to measure quality of life in young children affected by atopic dermatitis, and their parents. Objectives To evaluate the responsiveness (sensitivity to change), smallest detectable change (SDC) and minimal important change (MIC) of the CADIS. Methods Parents and primary caregivers of 300 young children completed the CADIS and a global rating of their child's skin condition at baseline and a 4-week follow-up. Kruskal-Wallis tests, Wilcoxon tests and effect sizes were used to assess responsiveness. The SDC can be seen as a change beyond measurement error. Anchor-based and distribution-based methods, and an integration of both methods were used to estimate the MIC. Results In total, 270 families provided data at baseline and 228 at follow-up. The CADIS total change score and most of the domain scores had moderate-to-strong correlations with the skin change score. Patients were grouped according to the skin change score, which served as an anchor. Children whose parents noted an improvement of the skin showed lower CADIS scores at follow-up (P < 0 center dot 001). For the SDC we obtained score changes of 1 center dot 34 points on the total score and MIC values passed the SDC cut-off. Conclusions The CADIS is sensitive to change towards improvement of quality of life. A change > 12% on the total score or each domain score very likely represents a clinically important change.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUALITY-OF-LIFE; CLINICALLY IMPORTANT DIFFERENCES; INITIAL VALIDATION; HEALTH-STATUS; CHILDREN; ECZEMA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Medical Sociology |
| Depositing User: | Petra Gürster |
| Date Deposited: | 03 Apr 2020 07:00 |
| Last Modified: | 03 Apr 2020 07:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26402 |
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