Schoisswohl, Stefan and Agrawal, Kushal and Simoes, Jorge and Neff, Patrick and Schlee, Winfried and Langguth, Berthold and Schecklmann, Martin (2019) RTMS parameters in tinnitus trials: a systematic review. SCIENTIFIC REPORTS, 9: 12190. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Over the past few years extensive body of research was produced investigating the effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of chronic tinnitus with heterogeneous results. This heterogeneity is exemplified by two recently published large-scale clinical trials reporting different outcomes. Technical aspects of rTMS were suspected as a potential source for this incongruency. The aim of this systematic review is to examine the overall efficacy as well as to identify possible technical factors relevant for the effectiveness of rTMS tinnitus trials. Via a literature search appropriate original research papers were identified and rTMS parameters were extracted from each study arm for subsequent statistical analysis with respect to observed effects (significant vs. not significant pre-post rTMS effects). Our findings indicate that verum rTMS is superior to sham rTMS as demonstrated by the proportion of significant pre-post contrasts. Some relevant rTMS parameters (e.g., pulse waveform) are not reported. Lower rTMS stimulation intensity was associated with significant effects in verum rTMS arms. An additional stimulation of the DLPFC to the temporal cortex was not found to promote efficacy. Future research should consider differential effects of rTMS induced by technical parameters and strive for an exhaustive reporting of relevant rTMS parameters.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; THETA-BURST STIMULATION; AUDITORY-CORTEX; TEMPOROPARIETAL JUNCTION; BRAIN-STIMULATION; DOUBLE-BLIND; TREATMENT OUTCOMES; EFFICACY; COIL; DEPRESSION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Mar 2020 12:33 |
| Last Modified: | 31 Mar 2020 12:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26417 |
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