Kappelmann-Fenzl, Melanie and Gebhard, Claudia and Matthies, Alexander O. and Kuphal, Silke and Rehli, Michael and Bosserhoff, Anja Katrin (2019) C-Jun drives melanoma progression in PTEN wild type melanoma cells. CELL DEATH & DISEASE, 10: 584. ISSN 2041-4889,
Full text not available from this repository. (Request a copy)Abstract
Due to the critical impact of active AP-1 transcription factors in melanoma, it is important to define their target genes and to identify and ultimately inhibit oncogenic signals. Here we mapped the genome-wide occupancy of the AP-1 family member c-Jun in different melanoma cells and correlated AP-1 binding with transcriptome data to detect genes in melanoma regulated by c-Jun. Our analysis shows that c-Jun supports the malignant phenotype by deregulating genes in cancer-relevant signaling pathways, such as mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K) pathways. Moreover, we demonstrate that the importance of c-Jun depends on melanoma stage and mutation status of the tumor suppressor PTEN. Our study reveals that activation of c-Jun overrules the tumor suppressive effect of PTEN in early melanoma development. These findings help to understand the relevance of c-Jun within cancer pathways in different melanoma cell types, especially in relation to MAPK and PI3K pathways, which are commonly deregulated in melanomas. Consequently, targeting c-Jun in PTEN+ melanoma cells may represent a promising therapeutic strategy to inhibit survival of melanoma cells to prevent the development of a metastatic phenotype.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THERAPEUTIC TARGET; CYCLIN D1; GENE; TRANSCRIPTION; EXPRESSION; PROLIFERATION; AP-1; PHOSPHORYLATION; SUPPRESSION; NETWORKS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Apr 2020 05:41 |
| Last Modified: | 01 Apr 2020 05:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26459 |
Actions (login required)
 |
View Item |
