Mietzner, Raphael and Breunig, Miriam (2019) Causative - glaucoma treatment: promising targets and delivery systems. DRUG DISCOVERY TODAY, 24 (8). pp. 1606-1613. ISSN 1359-6446, 1878-5832
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Glaucoma is one of the most common causes of blindness worldwide. Elevated intraocular pressure (IOP) is the major modifiable risk factor of the disease. Conventional therapy suffers from poor compliance, low bioavailability, and the lack of causative treatment options. To improve therapeutic success, it is crucial to identify major mediators of pathological changes associated with elevated IOP and to intervene at the molecular level. Here, we discuss relevant key functions of transforming growth factor-beta 2 (TGF-beta 2), connective tissue growth factor (CTGF), integrins, Rho-associated kinase (ROCK), and nitric oxide (NO) with regard to the onset of glaucoma, highlighting new drug delivery approaches for causative treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OPEN-ANGLE GLAUCOMA; EXTRACELLULAR-MATRIX PRODUCTION; GROWTH-FACTOR-BETA; TRABECULAR MESHWORK; NITRIC-OXIDE; INTRAOCULAR-PRESSURE; OUTFLOW FACILITY; ELEVATED LEVELS; DRUG-DELIVERY; CELL-DEATH; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 02 Apr 2020 06:12 |
| Last Modified: | 02 Apr 2020 06:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26480 |
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