Ehrnsberger, Hans F. and Grasser, Marion and Grasser, Klaus D. (2019) Nucleocytosolic mRNA transport in plants: export factors and their influence on growth and development. JOURNAL OF EXPERIMENTAL BOTANY, 70 (15). pp. 3757-3763. ISSN 0022-0957, 1460-2431
Full text not available from this repository. (Request a copy)Abstract
In eukaryotes, the regulated transport of mRNAs from the cell nucleus to the cytosol is a critical step in the expression of protein-coding genes, as it links nuclear mRNA synthesis with cytosolic translation. The pre-mRNAs that are synthesised by RNA polymerase II are processed by 5'-capping, splicing, and 3'-polyadenylation. The multi-subunit THO/TREX complex integrates mRNA biogenesis with their nucleocytosolic transport. Various export factors are recruited to the mRNAs during their maturation, which occurs essentially co-transcriptionally. These RNA-bound export factors ensure efficient transport of the export-competent mRNAs through nuclear pore complexes. In recent years, several factors involved in plant mRNA export have been functionally characterised. Analysis of mutant plants has demonstrated that impaired mRNA export causes defects in growth and development. Moreover, there is accumulating evidence that mRNA export can influence processes such as plant immunity, circadian regulation, and stress responses. Therefore, it is important to learn more details about the mechanism of nucleocytosolic mRNA transport in plants and its physiological significance.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARABIDOPSIS HOMOLOG; STRESS RESPONSES; GENE-EXPRESSION; NUCLEAR EXPORT; ALY PROTEINS; COMPLEX; COMPONENTS; TREX; INTERACTS; YRA1P; ALY; MOS11; mRNA export; RNA helicase; THO/TREX; TREX-2; UAP56; UIEF |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Pflanzenwissenschaften > Lehrstuhl für Zellbiologie und Pflanzenphysiologie (Prof. Dr. Klaus Grasser) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 03 Apr 2020 06:06 |
| Last Modified: | 03 Apr 2020 06:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26485 |
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