Markus, Marcello Ricardo Paulista and Werner, Nicole and Schipf, Sabine and Siewert-Markus, Ulrike and Bahls, Martin and Baumeister, Sebastian Edgar and Voelzke, Henry and Felix, Stephan Burkhard and Ittermann, Till and Doerr, Marcus (2017) Changes in Body Weight and Composition Are Associated With Changes in Left Ventricular Geometry and Function in the General Population: SHIP (Study of Health in Pomerania). CIRCULATION-CARDIOVASCULAR IMAGING, 10 (3): e005544. ISSN 1941-9651, 1942-0080
Full text not available from this repository. (Request a copy)Abstract
Background-The different effects of total body weight (TBW), fat-free mass (FFM), and fat mass (FM) on left ventricular (LV) geometry and function are complex. We investigated the associations of changes over time in TBW, FM, and FFM with changes in LV geometry and function. Methods and Results-We analyzed data from 1189 subjects (694 women), aged 44 to 86 years, from the baseline and the 5-year follow-up examination of the population-based SHIP (Study of Health in Pomerania). TBW was measured, and FFM and FM were calculated based on height-weight models derived from bioelectrical impedance studies. Echocardiographic measurements of LV geometry and function were performed according to the guidelines of the American Society of Echocardiography. Changes in body composition measures were associated with changes in LV geometry and function by multivariable-adjusted linear regression models. A 1-kg increase/decrease in TBW or FM was associated, respectively, with an increase/decrease of 0.89 g or 1.84 g in LV mass, whereas there was no such association on changes in FFM. Moreover, an increase in FM was associated with LV concentric remodeling and impairment of systolic and diastolic function parameters, whereas an increase in FFM was associated with LV eccentric remodeling and improved systolic and diastolic functional variables. Conclusions-Our findings indicate that changes in LV morphology and function depend on the type of body mass composition. Prospective data need to address whether specific changes in body composition over time may affect the risk for heart dysfunction more precisely than the change in TBW.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FAT-FREE MASS; ARTERIAL-HYPERTENSION; DIASTOLIC DYSFUNCTION; SLEEVE GASTRECTOMY; CARDIAC STRUCTURE; FAVORABLE CHANGES; BLOOD-PRESSURE; OBESE-PATIENTS; HYPERTROPHY; IMPACT; body composition; body weight; echocardiography; follow-up studies; obesity; ventricular function, left; ventricular mass, left |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:00 |
| Last Modified: | 25 Feb 2019 14:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/265 |
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