Treeck, Oliver and Buechler, Christa and Ortmann, Olaf (2019) Chemerin and Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20 (15): 3750. ISSN 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Chemerin is a multifunctional adipokine with established roles in inflammation, adipogenesis and glucose homeostasis. Increasing evidence suggest an important function of chemerin in cancer. Chemerin's main cellular receptors, chemokine-like receptor 1 (CMKLR1), G-protein coupled receptor 1 (GPR1) and C-C chemokine receptor-like 2 (CCRL2) are expressed in most normal and tumor tissues. Chemerin's role in cancer is considered controversial, since it is able to exert both anti-tumoral and tumor-promoting effects, which are mediated by different mechanisms like recruiting innate immune defenses or activation of endothelial angiogenesis. For this review article, original research articles on the role of chemerin and its receptors in cancer were considered, which are listed in the PubMed database. Additionally, we included meta-analyses of publicly accessible DNA microarray data to elucidate the association of expression of chemerin and its receptors in tumor tissues with patients' survival.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | C-FOS; DENDRITIC CELLS; TUMOR-GROWTH; MICROARRAY DATA; POOR-PROGNOSIS; GASTRIC-CANCER; EXPRESSION; PROGRESSION; SURVIVAL; CHEMR23; adipokine; chemerin; leukocyte; cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 02 Apr 2020 06:09 |
| Last Modified: | 02 Apr 2020 06:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26502 |
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