Groesser, Leopold and Singer, Sebastian and Peterhof, Eva and Landthaler, Michael and Heigl, Ulrike and Schneider-Brachert, Wulf and Berneburg, Mark and Hafner, Christian (2016) KRAS, HRAS and EGFR Mutations in Sporadic Sebaceous Gland Hyperplasia. ACTA DERMATO-VENEREOLOGICA, 96 (6). pp. 737-741. ISSN 0001-5555, 1651-2057
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Sporadic sebaceous gland hyperplasia (SGH) is a benign skin lesion, with a high prevalence in the general population. Although SGH has been attributed to both extrinsic and intrinsic factors, the underlying genetic changes have not yet been characterized. Recently, HRAS and KRAS mutations have been identified in sebaceous naevus, a hamartoma sharing histological characteristics with SGH. Therefore we screened 43 SGH for activating mutations in RAS genes and other oncogenes. We identified a wide spectrum of mutually exclusive activating HRAS (8/43), KRAS (11/43) and EGFR mutations (7/31) in altogether 60% of the lesions investigated. A RAS and EGFR wildtype status was found in 15 normal sebaceous glands in the head and neck area. Our findings indicate that activating HRAS, KRAS and EGFR mutations play a major role in the pathogenesis of sporadic SGH. These results support the concept that SGH is a true benign neoplasm rather than a reactive hyperplasia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR RECEPTOR; MICE; KERATOSIS; PIK3CA; BRAF; SKIN; HRAS; KRAS; EGFR; sebaceous gland hyperplasia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2019 13:03 |
| Last Modified: | 14 Mar 2019 07:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2651 |
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