Gakis, Georgios and Efstathiou, Jason A. and Daneshmand, Siamak and Keegan, Kirk A. and Clayman, Rebecca H. and Hrbacek, Jan and Ali-El-Dein, Bedeir and Zaid, Harras B. and Schubert, Tina and Mischinger, Johannes and Todenhoefer, Tilman and Galland, Sigolene and Olugbade, Kola and Rink, Michael and Fritsche, Hans-Martin and Burger, Maximilian and Chang, Sam S. and Babjuk, Marko and Thalmann, George N. and Stenzl, Arnulf and Morgan, Todd M. (2016) Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma. UROLOGIA INTERNATIONALIS, 97 (2). pp. 134-141. ISSN 0042-1138, 1423-0399
Full text not available from this repository. (Request a copy)Abstract
Introduction: The study aimed to investigate oncological outcomes of patients with concomitant bladder cancer (BC) and urethral carcinoma. Methods: This is a multicenter series of 110 patients (74 men, 36 women) diagnosed with urethral carcinoma at 10 referral centers between 1993 and 2012. Kaplan Meier analysis was used to investigate the impact of BC on survival, and Cox regression multivariable analysis was performed to identify predictors of recurrence. Results: Synchronous BC was diagnosed in 13 (12%) patients, and the median follow-up was 21 months (interquartile range 4-48). Urethral cancers were of higher grade in patients with synchronous BC compared to patients with non-synchronous BC (p = 0.020). Patients with synchronous BC exhibited significantly inferior 3-year recurrence-free survival (RFS) compared to patients with non-synchronous BC (63.2 vs. 34.4%; p = 0.026). In multivariable analysis, inferior RFS was associated with clinically advanced nodal stage (p < 0.001), proximal tumor location (p < 0.001) and synchronous BC (p = 0.020). Conclusion: The synchronous presence of BC in patients diagnosed with urethral carcinoma has a significant adverse impact on RFS and should be an impetus for a multimodal approach. (C) 2016 5. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTERNATIONAL COLLABORATION; PROGNOSTIC-FACTORS; URINARY-BLADDER; CANCER; SURVIVAL; TUMORS; TRACT; Bladder cancer; Lymph node; Prognosis; Radical cystectomy; Risk factor; Survival; Urethra |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Mar 2019 12:01 |
| Last Modified: | 18 Mar 2019 12:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2660 |
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