Enkirch, Theresa and Severi, Ettore and Vennema, Harry and Thornton, Lelia and Dean, Jonathan and Borg, Maria-Louise and Ciccaglione, Anna Rita and Bruni, Roberto and Christova, Iva and Ngui, Siew Lin and Balogun, Koye and Nemecek, Vratislav and Kontio, Mia and Takacs, Maria and Hettmann, Andrea and Korotinska, Rita and Love, Arthur and Avellon, Ana and Munoz-Chimeno, Milagros and de Sousa, Rita and Janta, Denisa and Epstein, Jevgenia and Klamer, Sofieke and Suin, Vanessa and Aberle, Stephan W. and Holzmann, Heidemarie and Mellou, Kassiani and Ederth, Josefine Lundberg and Sundqvist, Lena and Roque-Afonso, Anne-Marie and Filipovic, Sanja Kurecic and Poljak, Mario and Vold, Line and Stene-Johansen, Kathrine and Midgley, Sofie and Fischer, Thea Kolsen and Faber, Mirko and Wenzel, Juergen J. and Takkinen, Johanna and Leitmeyer, Katrin (2019) Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virus. EUROSURVEILLANCE, 24 (28). pp. 13-23. ISSN 1560-7917,
Full text not available from this repository. (Request a copy)Abstract
Introduction: Sequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)-wide outbreak related to frozen berries. However, as the sequenced HAV genome regions were only partly comparable between countries, results were not always conclusive. Aim: The objective was to gather information on HAV surveillance and sequencing in EU/European Economic Area (EEA) countries to find ways to harmonise their procedures, for improvement of cross-border outbreak responses. Methods: In 2014, the European Centre for Disease Prevention and Control (ECDC) conducted a survey on HAV surveillance practices in EU/EEA countries. The survey enquired whether a referral system for confirming primary diagnostics of hepatitis A existed as well as a central collection/storage of hepatitis A cases' samples for typing. Questions on HAV sequencing procedures were also asked. Based on the results, an expert consultation proposed harmonised procedures for cross-border outbreak response, in particular regarding sequencing. In 2016, a follow-up survey assessed uptake of suggested methods. Results: Of 31 EU/ EEA countries, 23 (2014) and 27 (2016) participated. Numbers of countries with central collection and storage of HAV positive samples and of those performing sequencing increased from 12 to 15 and 12 to 14 respectively in 2016, with all countries typing an overlapping fragment of 218 nt. However, variation existed in the sequenced genomic regions and their lengths. Conclusions: While HAV sequences in EU/EEA countries are comparable for surveillance, collaboration in sharing and comparing these can be further strengthened.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NETHERLANDS; INCREASE; STRAINS; MEN; SEX; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Apr 2020 05:43 |
| Last Modified: | 03 Apr 2020 05:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26637 |
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