Brachet, Etienne and Marzo, Leyre and Selkti, Mohamed and Koenig, Burkhard and Belmont, Philippe (2016) Visible light amination/Smiles cascade: access to phthalazine derivatives. CHEMICAL SCIENCE, 7 (8). pp. 5002-5006. ISSN 2041-6520, 2041-6539
Full text not available from this repository. (Request a copy)Abstract
We report the synthesis of various phthalazines via a new cascade reaction, initiated by visible light photocatalysis, involving a radical hydroamination reaction followed by a radical Smiles rearrangement. Phthalazine derivatives are obtained in high yields and from a broad scope readily accessible orthoalkynylsulfonohydrazone precursors. The mild photoredox conditions ensure an excellent functional group tolerance. Application of this strategy to a one-pot protocol starting from the corresponding carbonyl compounds, and subsequent functionalization allow the rapid synthesis of structurally diverse structures.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | C-H AMINATION; PHOTOREDOX CATALYSIS; HYDRAZONYL RADICALS; ORGANIC-SYNTHESIS; ALKENES; HETEROCYCLES; TRANSITION; ALKYNES; HYDROAMINATION; REARRANGEMENT; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Mar 2019 13:10 |
| Last Modified: | 18 Mar 2019 13:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2666 |
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