Wiesinger, I. and Schreml, S. and Wohlgemuth, W. A. and Stroszczynski, C. and Jung, E. M. (2016) Perfusion quantification of vascular malformations using contrast-enhanced ultrasound (CEUS) with time intensity curve analysis before and after treatment: First results. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 62 (4). pp. 283-290. ISSN 1386-0291, 1875-8622
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AIM: Aim of this pilot-study was to quantify perfusion changes of vascular malformations before and after the first interventional treatment using contrast-enhanced ultrasound (CEUS). MATERIAL AND METHODS: 29 patients (10 male, 19 female) between 6 and 63 years (mean 28.1 years) with 12 arteriovenous (AVM) and 17 venous malformations (VM) were examined before and after their first percutaneous interventional treatment. CEUS was performed with a 2.4 ml bolus injection of sulfur-hexafluorid microbubbles, and a 6-9MHz mulitfrequency transducer. A 60 sec cine sequence was recorded and regions of interest (10mmx30 mm) were defined in the centre, and the margins of the vascular malformation as well as in the surrounding healthy tissue. Time Intensity Curves (TIC) were analysed, and Time to Peak (TTP) as well as Area under the Curve (AUC) were calculated. RESULTS: For VMthere was a significant perfusion difference (p < 0.05) in AUC between centre and the surrounding tissue before (323.1 vs. 130.4 rU) and after treatment (331.0 vs. 106.9 rU). There was no significant difference for TTP in ROIs of VM (19.1 vs. 26.5 sec). After the treatment there was a significant decrease in AUC for all three regions in AVMs, and an increase in TTP for AVM. However TTP for AVM in the centre ROI still remained shorter than in the surrounding tissue even after therapy (20.9 vs. 25.4 sec). CONCLUSION: CEUS with TIC analysis is a promising imaging method for the evaluation of perfusion before and after percutaneous treatment of vascular malformations. AUC decrease indicates therapy-induced changes in perfusion of VM whereas an increase in TTP shows therapy-related changes in AVM.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUANTITATIVE ASSESSMENT; MICROVASCULARIZATION; TUMORS; Contrast-enhanced ultrasound (CEUS); venous malformation; arterio-venous malformation; TIC analysis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Mar 2019 13:43 |
| Last Modified: | 18 Mar 2019 13:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2671 |
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