Datz, Elisabeth and Zeman, Florian and Koller, Michael and Szeimies, Rolf-Markus and Berneburg, Mark and Landthaler, Michael and Bosserhoff, Anja K. and Karrer, Sigrid (2019) Phototherapy-induced elevation of serum level of melanoma inhibitory activity. PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 35 (4). pp. 255-260. ISSN 0905-4383, 1600-0781
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Background Phototherapy is a frequently used treatment modality for a variety of dermatologic diseases. UV radiation has different effects on the skin, for example increased production and release of cytokines and other proteins, and is involved in the initiation and progression of skin cancer. Objective of this clinical trial was to investigate potential systemic effects of UV phototherapy on cytokine profiles in blood. Methods In a prospective, mono-centric, one-armed study, the serum levels of the melanoma tumour marker "melanoma inhibitory activity" (MIA), Il-1 alpha, Il-4, Il-6, Il-10, TNF-alpha and IFN-gamma of 115 patients with different skin diseases were compared before and 24-48 hours as well as 2-4 weeks after the first phototherapy with PUVA (psoralen and ultraviolet A), UVA or UVB, or both. Data were analysed using linear mixed models. Results Estimated marginal means of MIA levels were 6.05 ng/mL (95%-CI: 5.37-6.72, range: 2.83-14.49) before the first treatment, which had significantly increased to 6.79 ng/mL 2-4 weeks after the first phototherapy (CI 95%: 6.12-7.47, range: 3.09-15.45; P = 0.0042). MIA levels 2-4 weeks after the first phototherapy were significantly higher than 24-48 hours after the first phototherapy (P = 0.0083). 2-4 weeks after the first treatment, TNF-alpha levels had decreased significantly (P = 0.033) more in patients with psoriasis who had responded well to phototherapy than in patients unresponsive to treatment. Serum levels of the other cytokines had not changed significantly. Conclusions Short-term phototherapy significantly increased the serum levels of the melanoma tumour marker MIA. The potential clinical relevance of these findings (ie an increased risk of melanoma) is unclear and should be further investigated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NECROSIS-FACTOR-ALPHA; TIME RT-PCR; MALIGNANT-MELANOMA; SKIN-CANCER; TNF-ALPHA; ULTRAVIOLET; PSORIASIS; MIA; PROGRESSION; TRANSCRIPTION; melanoma; melanoma inhibitory activity; phototherapy; psoriasis; skin diseases; study; UV therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Apr 2020 12:52 |
| Last Modified: | 03 Apr 2020 12:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26739 |
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