Evert, M. and Schildhaus, H-U (2019) Epithelioid, biphasic and mixed tumors of soft tissue. PATHOLOGE, 40 (4). pp. 393-411. ISSN 0172-8113, 1432-1963
Full text not available from this repository. (Request a copy)Abstract
Epithelioid soft tissue tumors consist exclusively of epithelioid tumor cells. Biphasic tumors are composed of both aspindle-cell and an epithelioid component. The rare mixed tumors of soft tissue show abroader variety of cellular and stromal differentiation but also include at least one, possibly several, epithelioid portions.The close morphological similarity of some of these entities with each other, as well as with the more frequent soft tissue metastases of carcinomas, carcinosarcomas, and melanomas, to malignant mesothelioma and certain lymphomas, can often make the correct diagnosis extremely difficult. Recent advances in the detection of certain molecular alterations (mostly chromosomal translocations) have contributed to changes in tumor classification but also to improved pathological diagnostics (e.g. through the development of potent diagnostic antibodies) and biological understanding.The present overview should help the pathologist in the diagnosis of these rare tumors through the classical approach of morphological pattern recognition. The most important entities are discussed and illustrated in more detail, with the incorporation of the latest immunohistochemical and molecular aspects and the differential diagnosis of similar tumors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CLEAR-CELL-SARCOMA; PART SARCOMA; IMMUNOHISTOCHEMICAL ANALYSIS; TENDONS; GENE; FIBROSARCOMA; APONEUROSES; NEOPLASMS; FUSIONS; VARIANT; Carcinosarcoma; Sarcoma; Histology; Molecular pathology; Soft tissue neoplasms |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 05:06 |
| Last Modified: | 06 Apr 2020 05:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26751 |
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