Weber, Daniela and Weber, Markus and Hippe, Katrin and Ghimire, Sakhila and Wolff, Daniel and Hahn, Joachim and Evert, Matthias and Herr, Wolfgang and Holler, Ernst and Jung, Ernst-Michael (2019) Non-invasive diagnosis of acute intestinal graft-versus-host disease by a new scoring system using ultrasound morphology, compound elastography, and contrast-enhanced ultrasound. BONE MARROW TRANSPLANTATION, 54 (7). pp. 1038-1048. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
Acute gastrointestinal (GI) graft-versus-host disease (GvHD) is a life-threating complication in patients after allogeneic stem cell transplantation (ASCT). In 60 sonographic analyses, a novel scoring system for non-invasive diagnosis of severe GI GvHD was developed. The score comprised morphological and vascular changes using B-mode and color-coded Doppler sonography, changes of mural stiffness using compound elastography, and dynamic microvascularisation using contrast-enhanced ultrasound (CEUS). Furthermore, inflammatory parameters such as CRP, Calprotectin, and regenerating islet-derived protein 3 alpha (Reg3 alpha) were obtained. ROC curve analysis of our novel GvHD sum score revealed an area under the curve of 1.0 (95% CI: 0.99-1.00) in diagnosing GI GvHD and 0.88 (95% CI: 0.79-0.96) for severe GI GvHD. A sum score above 5 correlated with GI GvHD with a sensitivity of 97.6% (41/42) and a specificity of 94.4% (17/18) and score values above 10 with severe GI GvHD with a sensitivity of 91.7% (11/12) and specificity of 79.2% (38/48). The additional use of inflammatory parameters did not improve the predictive power. CEUS is a promising, non-invasive tool for the diagnosis of acute GI GvHD. Together with further descriptive parameters for inflammatory processes, it gains significant diagnostic accuracy in identifying patients with severe stages of acute intestinal GvHD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FECAL CALPROTECTIN; CROHNS-DISEASE; GASTROINTESTINAL GVHD; BIOMARKER; CEUS; RECOMMENDATIONS; GUIDELINES; CRITERIA; PREDICT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Orthopädie Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 05:57 |
| Last Modified: | 06 Apr 2020 05:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26759 |
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