Zaenkert, Sandra and Bellingrath, Silja and Wuest, Stefan and Kudielka, Brigitte M. (2019) HPA axis responses to psychological challenge linking stress and disease: What do we know on sources of intra- and interindividual variability? PSYCHONEUROENDOCRINOLOGY, 105. pp. 86-97. ISSN 0306-4530,
Full text not available from this repository. (Request a copy)Abstract
Stress is an ubiquitous phenomenon with significant impact on human physiology when it lasts too long, when it is too intense, or when it hits vulnerable individuals. Examining the mechanisms linking stress exposure with health and disease is an important endeavor in psychoneuroendocrine research. Empirical evidence so far revealed large intra- as well as inter-individual variability in hypothalamic-pituitary-adrenal (HPA) axis responses to acute psychosocial stress, showing that the HPA axis is a highly adaptive system. Thus, the characterization of intra- and inter-individual patterns of HPA axis reactivity is of high scientific interest and forms the basis on which mechanistic links between stress response (dys)regulation and health impairments can be examined. To date, basic knowledge has been, and still is, accumulated on demographic, biological (including genetic and epigenetic) factors, lifestyle behavioral variables, consumption of substances and medication, psychological and personality factors, as well as on methodological aspects. Besides this, there is also very recent progress in respect to the development of laboratory stress paradigms that can be applied in virtual reality or inside an MRIscanner. In sum, the present review updates our current knowledge on moderating and intervening factors as sources of intra- and inter-individual variability in human cortisol stress responses and offers recommendations for future research designs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PITUITARY-ADRENAL-AXIS; TRIER SOCIAL STRESS; ACUTE PSYCHOSOCIAL STRESS; GENE-ENVIRONMENT INTERACTIONS; CORTISOL AWAKENING RESPONSE; S RECEPTOR GENE; SALIVARY CORTISOL; SEX-DIFFERENCES; PHYSIOLOGICAL-RESPONSES; PHARMACOLOGICAL CHALLENGE; Acute stress; Cortisol; HPA axis; Trier social stress test (TSST); Human; saliva |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie VII (Medizinische Psychologie, Psychologische Diagnostik und Methodenlehre) - Prof. Dr. Brigitte Kudielka |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 06:50 |
| Last Modified: | 06 Apr 2020 06:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26772 |
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