Vianello, Elena and Massimiliano, Maria Marrocco-Trischitta and Dozio, Elena and Bandera, Francesco and Tacchini, Lorenza and Canciani, Elena and Dellavia, Claudia and Schmitz, Gerd and Lorenzo, Menicanti and Massimiliano, Marco Corsi Romanelli (2019) Correlational study on altered epicardial adipose tissue as a stratification risk factor for valve disease progression through IL-13 signaling. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 132. pp. 210-218. ISSN 0022-2828, 1095-8584
Full text not available from this repository. (Request a copy)Abstract
Aims: Genetic and environmental factors all interact in the risk of progression of valvular dysfunctions. Previous studies reported a relation between valve diseases and epicardial adipose tissue (EAT) thickness. The aim of this study was to verify the possible relationship between the molecular pattern of EAT related to IL-13 fibrogenic cytokine expression and valve dysfunction. Methods and results: A valvular heart disease (VHD) population was stratified according to their median EAT thickness (7 mm). The molecular expression of IL-13 in EAT is directly related to the molecular expression of genes associated with extracellular matrix (ECM) turnover, macrophage infiltration and promotion of the formation of ectopic calcific nodules involved in aorta coarctation and calcification. Conclusion: IL-13 gene expression in altered EAT is directly related to the expression of genes involved in ECM turnover and the formation of ectopic calcific nodules, suggesting measurements of EAT as a stratification risk factor for valve instability in the VHD patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AORTIC-VALVE; MOUSE MODEL; HEART; DIFFERENTIATION; INFLAMMATION; RECEPTOR; Valvular heart disease (VHD); Epicardial adipose tissue (EAT); IL-13; TGF beta 1; Bone morphogenic proteins (BMPs); Wnt |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 06:52 |
| Last Modified: | 06 Apr 2020 06:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26775 |
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