Bludau, Anna and Royer, Melanie and Meister, Gunter and Neumann, Inga D. and Menon, Rohit (2019) Epigenetic Regulation of the Social Brain. TRENDS IN NEUROSCIENCES, 42 (7). pp. 471-484. ISSN 0166-2236, 1878-108X
Full text not available from this repository. (Request a copy)Abstract
Social behavior, a highly adaptive and crucial component of mammalian life, is regulated by particularly sensitive regulatory brain mechanisms. Substantial evidence implicates classical epigenetic mechanisms including histone modifications, DNA methylation, and nucleosome remodeling as well as nonclassical mechanisms mediated by noncoding RNA in the regulation of social behavior. These mechanisms collectively form the 'epigenetic network' that orchestrates genomic integration of salient and transient social experiences. Consequently, its dysregulation has been linked to behavioral deficits and psychopathologies. This review focuses on the role of the epigenetic network in regulating the enduring effects of social experiences during early-life, adolescence, and adulthood. We discuss research in animal models, primarily rodents, and associations between dysregulation of epigenetic mechanisms and human psychopathologies, specifically autism spectrum disorder (ASD) and schizophrenia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RECEPTOR GENE OXTR; CHROMATIN-REMODELING COMPLEX; DNA-METHYLATION CHANGES; ANXIETY-LIKE BEHAVIOR; EARLY-LIFE STRESS; OXYTOCIN RECEPTOR; PREFRONTAL CORTEX; MOUSE MODEL; MATERNAL SEPARATION; VALPROIC ACID; |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Petra Gürster |
| Date Deposited: | 31 Mar 2020 07:51 |
| Last Modified: | 31 Mar 2020 07:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26777 |
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