Guzzi, Louis M. and Bergler, Tobias and Binnall, Brian and Engelman, Daniel T. and Forni, Lui and Germain, Michael J. and Gluck, Eric and Goecze, Ivan and Joannidis, Michael and Koyner, Jay L. and Reddy, V. Seenu and Rimmele, Thomas and Ronco, Claudio and Textoris, Julien and Zarbock, Alexander and Kellum, John A. (2019) Clinical use of [TIMP-2]center dot[IGFBP7] biomarker testing to assess risk of acute kidney injury in critical care: guidance from an expert panel. CRITICAL CARE, 23: 225. ISSN 1466-609X, 1364-8535
Full text not available from this repository. (Request a copy)Abstract
BackgroundThe first FDA-approved test to assess risk for acute kidney injury (AKI), [TIMP-2]center dot[IGFBP7], is clinically available in many parts of the world, including the USA and Europe. We sought to understand how the test is currently being used clinically.MethodsWe invited a group of experts knowledgeable on the utility of this test for kidney injury to a panel discussion regarding the appropriate use of the test. Specifically, we wanted to identify which patients would be appropriate for testing, how the results are interpreted, and what actions would be taken based on the results of the test. We used a modified Delphi method to prioritize specific populations for testing and actions based on biomarker test results. No attempt was made to evaluate the evidence in support of various actions however.ResultsOur results indicate that clinical experts have developed similar practice patterns for use of the [TIMP-2]center dot[IGFBP7] test in Europe and North America. Patients undergoing major surgery (both cardiac and non-cardiac), those who were hemodynamically unstable, or those with sepsis appear to be priority patient populations for testing kidney stress. It was agreed that, in patients who tested positive, management of potentially nephrotoxic drugs and fluids would be a priority. Patients who tested negative may be candidates for fast-track protocols.ConclusionIn the experience of our expert panel, biomarker testing has been a priority after major surgery, hemodynamic instability, or sepsis. Our panel members reported that a positive test prompts management of nephrotoxic drugs as well as fluids, while patients with negative results are considered to be excellent candidates for fast-track protocols.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CYCLE ARREST BIOMARKERS; URINARY TIMP-2; ADULTS; IMPACT; Biomarker testing; Acute kidney injury; Critical care; Expert panel; Protocols; Clinical guidelines; Tissue inhibitor of metalloproteinases-2; Insulin-like growth factor binding protein 7; Biomarker technology; Diagnosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 08:17 |
| Last Modified: | 06 Apr 2020 08:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26817 |
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