Mycielska, Maria E. and Mohr, Markus T. J. and Schmidt, Katherina and Drexler, Konstantin and Ruemmele, Petra and Haferkamp, Sebastian and Schlitt, Hans J. and Gaumann, Andreas and Adamski, Jerzy and Geissler, Edward K. (2019) Potential Use of Gluconate in Cancer Therapy. FRONTIERS IN ONCOLOGY, 9: 522. ISSN 2234-943X,
Full text not available from this repository. (Request a copy)Abstract
We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decreased tumor growth and altered metabolic characteristics of tumor tissue. Interestingly, gluconate, considered to be physiologically neutral, is incidentally used in medicine as a cation carrier, but not as a therapeutically active substance. In this review we discuss the results of our recent research with available literature and suggest that gluconate may be useful in the treatment of cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SODIUM STIBOGLUCONATE; MAGNESIUM INFUSIONS; PHASE-II; IN-VITRO; DISULFIRAM; PREVENTION; ANTIMONY; CALCIUM; CELLS; IMMUNOTHERAPY; gluconate; cancer metabolism; citrate; metabolic targeting; transporter |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2020 08:38 |
| Last Modified: | 06 Apr 2020 08:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26820 |
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