Rennert, Janine and Wiesinger, Isabel and Schicho, Andreas and Beyer, Lukas Philip and Wiggermann, Philipp and Stroszczynski, Christian and Jung, Ernst Michael (2019) Color coded perfusion imaging with contrast enhanced ultrasound (CEUS) for post-interventional success control following transarterial chemoembolization (TACE) of hepatocellular carcinoma. PLOS ONE, 14 (6): UNSP e0217. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Aim Evaluation of an external color coded perfusion quantification software with CEUS for the post-interventional success control following TACE in patients with HCC. Material and methods 31 patients (5 females, 26 males, age range 34-82 years, mean 66.8 years) with 59 HCC lesions underwent superselective TACE using DSM Beads between 01/2015 and 06/2018. All patients underwent CEUS by an experienced examiner using a convex multifrequency probe (1-6 MHz) within 24 hours following TACE to detect residual tumor tissue. Retrospective evaluation using a perfusion quantification software regarding pE, TTP, mTT, Ri and WiAUC in the center of the lesion, the margin and surrounding liver. Results In all lesions, a post-interventional visual reduction of the tumor microvascularization was observed. Significant differences between center of the lesion vs. margin and surrounding liver were found regarding peak enhancement (867.8 +/- 2416 center vs 2028 +/- 3954 margin p< 0.005) and center 867.8 +/- 2416 vs 2824 +/- 4290 surrounding liver, p<0.0001)). However, no significant differences were found concerning Ri, WiAuC, mTT and TTP. Conclusion CEUS with color-coded perfusion imaging is a valuable supporting tool for post-interventional success control following TACE of liver lesions. Peak enhancement seems to be the most valuable parameter.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CLINICAL-PRACTICE GUIDELINES; LIVER-TRANSPLANTATION; MANAGEMENT; ABLATION; EFFICACY; COHORT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Apr 2020 09:52 |
| Last Modified: | 08 Apr 2020 09:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26841 |
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