Klampfl, Stefanie M. and Bosch, Oliver J. (2019) When mothers neglect their offspring: an activated CRF system in the BNST is detrimental for maternal behavior. ARCHIVES OF WOMENS MENTAL HEALTH, 22 (3). pp. 409-415. ISSN 1434-1816, 1435-1102
Full text not available from this repository. (Request a copy)Abstract
Becoming a mother is an intense experience that not only changes a woman's life but is also paralleled by multiple central adaptations. These changes evolve before parturition and continue to persist into lactation, thereby ensuring the full commitment of the mother to care for the newborns. Most of our knowledge on these adaptations that drive the peripartum brain come from rodent animal models. On one side, it is known that maternal behavior is initiated and maternal mood is stabilized by an upregulation of the pro-maternal neuropeptide systems' activity of oxytocin and arginine-vasopressin. On the other side, signaling of the rather anti-maternal corticotropin-releasing factor system triggers maternal neglect and increases maternal anxiety. Here, we discuss how the corticotropin-releasing factor system based in the limbic bed nucleus of the stria terminalis negatively affects maternal behavior and maternal mood. Moreover, we apply microdialysis and acute pharmacological interventions to demonstrate how the corticotropin-releasing factor system potentially interacts with the pro-maternal oxytocin system in the posterior bed nucleus of the stria terminalis to trigger certain aspects of maternal behavior.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORTICOTROPIN-RELEASING-FACTOR; STRIA TERMINALIS; BED NUCLEUS; FACTOR-RECEPTOR; BINDING-PROTEIN; STRESS; OXYTOCIN; BRAIN; RAT; PROJECTIONS; Anxiety; Bed nucleus of the stria terminalis; Corticotropin-releasing factor; Maternal neglect; Oxytocin |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Apr 2020 08:56 |
| Last Modified: | 14 Apr 2020 08:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26931 |
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