Dorst, Johannes and Chen, Lu and Rosenbohm, Angela and Dreyhaupt, Jens and Huebers, Annemarie and Schuster, Joachim and Weishaupt, Jochen H. and Kassubek, Jan and Gess, Burkhard and Meyer, Thomas and Weyen, Ute and Hermann, Andreas and Winkler, Juergen and Grehl, Torsten and Hagenacker, Tim and Lingor, Paul and Koch, Jan C. and Sperfeld, Anne and Petri, Susanne and Grosskreutz, Julian and Metelmann, Moritz and Wolf, Joachim and Winkler, Andrea S. and Klopstock, Thomas and Boentert, Matthias and Johannesen, Siw and Storch, Alexander and Schrank, Bertold and Zeller, Daniel and Liu, Xiao-lu and Tang, Lu and Fan, Dong-Sheng and Ludolph, Albert C. (2019) Prognostic factors in ALS: a comparison between Germany and China. JOURNAL OF NEUROLOGY, 266 (6). pp. 1516-1525. ISSN 0340-5354, 1432-1459
Full text not available from this repository. (Request a copy)Abstract
ObjectiveSeveral independent prognostic factors, such as age of onset, type of onset, body mass index (BMI), and progression rate have been identified for amyotrophic lateral sclerosis (ALS) in Caucasians. The aim of this study was to identify such factors in Chinese patients and to compare their impact with German patients.MethodsComparison of prognostic factors was based on two hospital-based registries. The registry of the German Network for Motor Neuron Diseases contains 3100 patients with ALS. The Chinese registry comprises 2101 patients who were collected between 2003 and 2015 in the metropolitan area of Beijing.ResultsDisease progression was slower in China [median loss of 0.50 points (IQR 0.26-0.87 points) versus 0.55 points (IQR 0.28-1.00 points) of ALS functional rating scale revised (ALS-FRS-R) score per month; p<0.0001]. Survival of patients with ALS was similar in Germany and China (p>0.05). We found that younger age of onset (p<0.0001), spinal onset (p<0.0001), high BMI (p<0.0001) and low progression rate (p<0.0001) were positive prognostic factors in China as well as in Germany.InterpretationPrognostic factors, which are known to modify the course of disease in Caucasians, apply to Chinese patients as well. The results indicate that despite the apparent differences regarding genotype and clinical phenotype, findings from interventional studies in Caucasians aiming at disease-modifying prognostic factors (such as body weight) may be transferred to Chinese patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AMYOTROPHIC-LATERAL-SCLEROSIS; EPIDEMIOLOGY; CRITERIA; DISEASE; Amyotrophic lateral sclerosis; Motor neuron disease; Prognostic factors; Survival; Germany; China |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Apr 2020 05:17 |
| Last Modified: | 08 Apr 2020 05:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26963 |
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