Cheng, Pi and Wang, Wei and Wang, Lin and Zeng, Jianguo and Reiser, Oliver and Liang, Yun (2019) Ag2CO3-mediated direct functionalization of alkyl nitriles: Facile synthesis of gamma-ketonitriles through nitrile alkylation of enol acetates. TETRAHEDRON LETTERS, 60 (21). pp. 1408-1412. ISSN 0040-4039,
Full text not available from this repository. (Request a copy)Abstract
Direct C(sp3)-H functionalization of alkyl nitriles is a low toxic and facile route to nitrile-containing compounds. In this research, the Ag2CO3-mediated nitrile methylenation of enol acetates is developed to prepare gamma-ketonitriles through the direct C(sp(3))-H oxidative functionalization of acetonitrile. A radical pathway is proposed, and acetonitrile serves both as solvent and CN-containing radical source. (C) 2019 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUBSTITUTED VINYL ACETATES; CONJUGATE CYANATION; CYCLIZATION; CONSTRUCTION; ARYLATION; SULFONES; ALCOHOLS; ALKENES; OLEFINS; KETONES; Alkyl nitriles; Silver carbonate; Radical; Enol acetates; gamma-Ketonitriles |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Apr 2020 06:50 |
| Last Modified: | 08 Apr 2020 06:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/26983 |
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