Verloh, N. and Probst, U. and Utpatel, K. and Zeman, F. and Brennfleck, F. and Werner, J. M. and Fellner, C. and Stroszczynski, C. and Evert, M. and Wiggermann, P. and Haimerl, M. (2019) Influence of hepatic fibrosis and inflammation: Correlation between histopathological changes and Gd-EOB-DTPA-enhanced MR imaging. PLOS ONE, 14 (5): e0215752. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Objective To evaluate the influence of an active inflammatory process in the liver on Gd-EOB-DTPA-enhanced MR imaging in patients with different degrees of fibrosis/cirrhosis. Material and methods Overall, a number of 91 patients (61 men and 30 women; mean age 58 years) were included in this retrospective study. The inclusion criteria for this study were Gd-EOB-DTPA-enhanced MRI of the liver and histopathological evaluation of fibrotic and inflammatory changes. T1-weighted VIBE sequences of the liver with fat suppression were evaluated to determine the relative signal change (RE) between native and hepatobiliary phase (20 min). In simple and multiple linear regression analyses, the influence of liver fibrosis/cirrhosis (Ishak score) and the histopathological degree of hepatitis (Modified Hepatic Activity Index, mHAI) on RE were evaluated. Results RE decreased significantly with increasing liver fibrosis/cirrhosis (p < 0.001) and inflammation (mHAI, p = 0.004). In particular, a correlation between RE and periportal or periseptal boundary zone hepatitis (moth feeding necrosis, mHAI A, p = 0.001) and portal inflammation (mHAI D, p < 0.001) was observed. In multiple linear regression analysis, both the degree of inflammation and the degree of fibrosis were significant predictors for RE (p < 0.01). Conclusion The results of this study suggest that the MR-based hepatic enhancement index RE is not only influenced by the degree of fibrosis, but also by the degree of inflammation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LIVER FIBROSIS; GADOXETIC ACID; NONALCOHOLIC STEATOHEPATITIS; ELASTOGRAPHY; MECHANISMS; STEATOSIS; DIAGNOSIS; CIRRHOSIS; BIOPSY; NASH; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Apr 2020 05:22 |
| Last Modified: | 15 Apr 2020 05:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27015 |
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