Voigt, Niels and Ort, Katharina and Sossalla, Samuel (2019) Drug Interactions that you need to know! (Reprinted). FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE, 87 (5). pp. 320-332. ISSN 0720-4299, 1439-3522
Full text not available from this repository. (Request a copy)Abstract
Arzneimittelinteraktionen (AMI) sind ein haufig unterschatztes Problem der modernen Medizin. Die Zahl alterer, multimorbider Patienten, die mehrere Wirkstoffe gleichzeitig einnehmen, nimmt stetig zu-der damit verbundene exponentielle Anstieg moglicher AMI ist fast unuberschaubar. Diese ubersicht stellt haufige, relevante AMI anhand von Beispielen dar und zeigt Strategien auf, wie sie in der Praxis fruhzeitig erkannt und vermieden werden konnen. Drug-drug interactions (DDI) represent a significant problem in modern medicine. The number of patients with multi-morbidity, who take multiple drugs, is constantly increasing (polypharmacy). The related exponential increase in potential DDI is almost incomprehensible. In this article, we review pharmacodynamic DDI and provide clinically relevant examples. In addition, we extensively review pharmakokinetic DDI (e.g. through the cytochrome P450-system or p-glycoproteins) that can modify the plasma concentration of many compounds, thereby also increasing the likelihood of unwanted side effects. Finally we provide tools, which may help clinicians in their daily practice to identify and avoid potential DDI. In the context of an ageing society receiving polypharmacy, a better awareness of DDI and of strategies to prevent them is expected to reduce mortality and morbidity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SEROTONIN REUPTAKE INHIBITORS; ASSOCIATION; MECHANISMS; RISK; Arzneimittelinteraktionen; Cytochrom P450; Polypharmazie; Pharmakokinetik; Pharmakodynamik; drug-drug interactions; cytochrome P450; polypharmacy; pharmacokinetics; pharmacodynamics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2020 06:35 |
| Last Modified: | 25 Mar 2020 06:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27050 |
Actions (login required)
 |
View Item |
