Mustroph, Julian and Lebek, Simon and Maier, Lars S. and Neef, Stefan (2019) Mechanisms of cardiac ethanol toxicity and novel treatment options. PHARMACOLOGY & THERAPEUTICS, 197. pp. 1-10. ISSN 0163-7258
Full text not available from this repository. (Request a copy)Abstract
Ethanol can acutely and chronically alter cardiomyocyte and whole-organ function in the heart. Importantly, ethanol acutely and chronically predisposes to arrhythmias, while chronic abuse can induce heart failure. However, the molecular mechanisms of ethanol toxicity in the heart are incompletely understood. In this review, we summarize the current mechanistic knowledge on cardiac ethanol toxicity, with a focus on druggable pathways. Ethanol effects on excitation-contraction coupling, oxidative stress, apoptosis, and cardiac metabolism, as well as effects of ethanol metabolites will be discussed. Important recent findings have been gained by investigation of acute ethanol effects. These include a renewed focus on reactive oxygen species (ROS) and induction of SR Ca2+ leak by CaMKII-mediated pathways downstream of ROS. Furthermore, a clinical outlook into potential novel treatment options is provided. (C) 2018 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LEFT-VENTRICULAR FUNCTION; ALDEHYDE DEHYDROGENASE 2; PROTEIN-KINASE-II; INDUCED MYOCARDIAL DYSFUNCTION; CHRONIC ALCOHOL INGESTION; CONTRACTILE DYSFUNCTION; ATRIAL-FIBRILLATION; OXIDATIVE STRESS; DEPENDENT KINASE; DILATED CARDIOMYOPATHY; Ethanol; Heart; Alcohol; Cardiomyocytes; Arrhythmogenesis; CaMKII |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Petra Gürster |
| Date Deposited: | 30 Mar 2020 08:55 |
| Last Modified: | 30 Mar 2020 08:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27057 |
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