Riechers, Elke and Baerlecken, Niklas and Baraliakos, Xenofon and Bakhsh, Katrin Achilles-Mehr and Aries, Peer and Bannert, Bettina and Becker, Klaus and Brandt-Juergens, Jan and Braun, Juergen and Ehrenstein, Boris and Euler, Hans-Hartwig and Fleck, Martin and Hein, Reinhard and Karberg, Kirsten and Koehler, Lars and Matthias, Torsten and Max, Regina and Melzer, Adelheid and Meyer-Olson, Dirk and Rech, Juergen and Rockwitz, Karin and Rudwaleit, Martin and Schmidt, Reinhold E. and Schweikhard, Eva and Sieper, Joachim and Stille, Carsten and von Hinueber, Ulrich and Wagener, Peter and Weidemann, Heike-Franziska and Zinke, Silke and Witte, Torsten (2019) Sensitivity and Specificity of Autoantibodies Against CD74 in Nonradiographic Axial Spondyloarthritis. ARTHRITIS & RHEUMATOLOGY, 71 (5). pp. 729-735. ISSN 2326-5191, 2326-5205
Full text not available from this repository. (Request a copy)Abstract
ObjectiveAutoantibodies against CD74 (anti-CD74) are associated with ankylosing spondylitis (AS). The present multicenter study, the International Spondyloarthritis Autoantibody (InterSpA) trial, was undertaken to compare the sensitivity and specificity of anti-CD74 and HLA-B27 in identifying patients with nonradiographic axial spondyloarthritis (axSpA). MethodsPatients ages 18-45 years with inflammatory back pain of 2 years' duration and a clinical suspicion of axSpA were recruited. HLA-B27 genotyping and magnetic resonance imaging of sacroiliac joints were performed in all patients. One hundred forty-nine patients with chronic inflammatory back pain (IBP) not caused by axSpA served as controls, and additional controls included 50 AS patients and 100 blood donors whose specimens were analyzed. ResultsOne hundred patients with inflammatory back pain received a diagnosis of nonradiographic axSpA from the investigators and fulfilled the Assessment of SpondyloArthritis international Society (ASAS) criteria. The mean age was 29 years, and the mean symptom duration was 12.5 months. The sensitivity of IgA anti-CD74 and IgG anti-CD74 for identifying the 100 axSpA patients was 47% and 17%, respectively. The specificity of both IgA anti-CD74 and IgG anti-CD74 was 95.3%. The sensitivity of HLA-B27 was 81%. The positive likelihood ratios were 10.0 (IgA anti-CD74), 3.6 (IgG anti-CD74), and 8.1 (HLA-B27). Assuming a 5% pretest probability of axSpA in chronic back pain patients, the posttest probability, after consideration of the respective positive test results, was 33.3% for IgA anti-CD74, 15.3% for IgG anti-CD74, and 28.8% for HLA-B27. A combination of IgA anti-CD74 and HLA-B27 results in a posttest probability of 80.2%. ConclusionIgA anti-CD74 may be a useful tool for identifying axSpA. The diagnostic value of the test in daily practice requires further confirmation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY BACK-PAIN; ANKYLOSING-SPONDYLITIS; HIGH PREVALENCE; CLASSIFICATION; CRITERIA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Apr 2020 06:22 |
| Last Modified: | 09 Apr 2020 06:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27066 |
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