Reinders, Yvonne and Meier, Robert J. and Liebsch, Gregor and Pohl, Fabian and Schreml, Stephan and Prantl, Lukas and Haubner, Frank (2019) Imaging of pH and pO(2) gives insight in molecular processes of irradiated cells. EXPERIMENTAL DERMATOLOGY, 28 (5). pp. 628-630. ISSN 0906-6705, 1600-0625
Full text not available from this repository. (Request a copy)Abstract
One of the major challenges in radiation therapy is the interference with tissue repair processes due to hypoxic characteristics and pH dysregulation. In this study, we present dual imaging of pH and oxygenation in vitro based on luminescent biocompatible sensor foils that allow studying the effects of irradiation on different cell types in culture. Different sensitivities of fibroblast and oral squamous carcinoma cells were observed by complementing oxygen and pH differences with proliferation assays. This study highlights especially the distinct role of oxygen after irradiation and the difference in proliferation processes of irradiated normal dermal cells in contrast to irradiated tumor cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RADIATION; dual imaging; oxygenation; radiation therapy; sensors; wound healing |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Strahlentherapie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Aug 2023 05:25 |
| Last Modified: | 03 Aug 2023 05:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27068 |
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