Brinker, Titus J. and Hekler, Achim and Enk, Alexander H. and Klode, Joachim and Hauschild, Axel and Berking, Carola and Schilling, Bastian and Haferkamp, Sebastian and Schadendorf, Dirk and Holland-Letz, Tim and Utikal, Jochen S. and von Kalle, Christof (2019) Deep learning outperformed 136 of 157 dermatologists in a head-to-head dermoscopic melanoma image classification task. EUROPEAN JOURNAL OF CANCER, 113. pp. 47-54. ISSN 0959-8049, 1879-0852
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Background: Recent studies have successfully demonstrated the use of deep-learning algorithms for dermatologist-level classification of suspicious lesions by the use of excessive proprietary image databases and limited numbers of dermatologists. For the first time, the performance of a deep-learning algorithm trained by open-source images exclusively is compared to a large number of dermatologists covering all levels within the clinical hierarchy. Methods: We used methods from enhanced deep learning to train a convolutional neural network (CNN) with 12,378 open-source dermoscopic images. We used 100 images to compare the performance of the CNN to that of the 157 dermatologists from 12 university hospitals in Germany. Outperformance of dermatologists by the deep neural network was measured in terms of sensitivity, specificity and receiver operating characteristics. Findings: The mean sensitivity and specificity achieved by the dermatologists with dermoscopic images was 74.1% (range 40.0%-100%) and 60% (range 21.3%-91.3%), respectively. At a mean sensitivity of 74.1%, the CNN exhibited a mean specificity of 86.5% (range 70.8%-91.3%). At a mean specificity of 60%, a mean sensitivity of 87.5% (range 80%-95%) was achieved by our algorithm. Among the dermatologists, the chief physicians showed the highest mean specificity of 69.2% at a mean sensitivity of 73.3%. With the same high specificity of 69.2%, the CNN had a mean sensitivity of 84.5%. Interpretation: A CNN trained by open-source images exclusively outperformed 136 of the 157 dermatologists and all the different levels of experience (from junior to chief physicians) in terms of average specificity and sensitivity. (C) 2019 The Author(s). Published by Elsevier Ltd.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ALGORITHMS; DIAGNOSIS; Melanoma; Skin cancer; Artificial intelligence |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Apr 2020 07:16 |
| Last Modified: | 09 Apr 2020 07:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27094 |
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