Baumeister, Sebastian E. and Schlesinger, Sabrina and Aleksandrova, Krasimira and Jochem, Carmen and Jenab, Mazda and Gunter, Marc J. and Overvad, Kim and Tjonneland, Anne and Boutron-Ruault, Marie-Christine and Carbonnel, Franck and Fournier, Agnes and Kuehn, Tilman and Kaaks, Rudolf and Pischon, Tobias and Boeing, Heiner and Trichopoulou, Antonia and Bamia, Christina and La Vecchia, Carlo and Masala, Giovanna and Panico, Salvatore and Fasanelli, Francesca and Tumino, Rosario and Grioni, Sara and de Mesquita, Bas Bueno and Vermeulen, Roel and May, Anne M. and Borch, Kristin B. and Oyeyemi, Sunday O. and Ardanaz, Eva and Rodriguez-Barranco, Miguel and Chirlaque Lopez, Maria Dolores and Felez-Nobrega, Mireia and Sonestedt, Emily and Ohlsson, Bodil and Hemmingsson, Oskar and Werner, Marten and Perez-Cornago, Aurora and Ferrari, Pietro and Stepien, Magdalena and Freisling, Heinz and Tsilidis, Konstantinos K. and Ward, Heather and Riboli, Elio and Weiderpass, Elisabete and Leitzmann, Michael F. (2019) Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study. JOURNAL OF HEPATOLOGY, 70 (5). pp. 885-892. ISSN 0168-8278, 1600-0641
Full text not available from this repository. (Request a copy)Abstract
Background & Aims: To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. Weexamined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). Methods: We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years). We estimated cause-specific hazard ratios (HRs) for total physical activity and vigorous physical activity and performed mediation analysis and secondary analyses to assess robustness to confounding (e.g. due to hepatitis virus infection). Results: In the EPIC cohort, the multivariable-adjusted HR of HCC was 0.55 (95% CI 0.38-0.80) comparing active and inactive individuals. Regarding vigorous physical activity, for those reporting >2 hours/week compared to those with no vigorous activity, the HR for HCC was 0.50 (95% CI 0.33-0.76). Estimates were similar in sensitivity analyses for confounding. Total and vigorous physical activity were unrelated to IHBC and NGBC. In mediation analysis, waist circumference explained about 40% and body mass index 30% of the overall association of total physical activity and HCC. Conclusions: These findings suggest an inverse association between physical activity and risk of HCC, which is potentially mediated by obesity. Lay summary: In a pan-European study of 467,336 men and women, we found that physical activity is associated with a reduced risk of developing liver cancers over the next decade. This risk was independent of other liver cancer risk factors, and did not vary by age, gender, smoking status, body weight, and alcohol consumption. (C) 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATOCELLULAR-CARCINOMA; VALIDITY; QUESTIONNAIRE; MORTALITY; OBESITY; DISEASE; BURDEN; Hepatobiliary cancer; Hepatocellular carcinoma; Liver cancer; Physical activity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Apr 2020 11:05 |
| Last Modified: | 09 Apr 2020 11:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27123 |
Actions (login required)
 |
View Item |
