Bonnot, Olivier and Kluenemann, Hans-Hermann and Velten, Christian and Martin, Juan Vicente Torres and Walterfang, Mark (2019) Systematic review of psychiatric signs in Niemann-Pick disease type C. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 20 (4). pp. 320-332. ISSN 1562-2975, 1814-1412
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Objectives: We conducted the first systematic literature review and analysis of psychiatric manifestations in Niemann-Pick disease type C (NPC) to describe: (1) time of occurrence of psychiatric manifestations relative to other disease manifestations; and (2) frequent combinations of psychiatric, neurological and visceral disease manifestations. Methods: A systematic EMBase literature search was conducted to identify, collate and analyze published data from patients with NPC associated with psychiatric symptoms, published between January 1967 and November 2015. Results: Of 152 identified publications 40 were included after screening that contained useable data from 58 NPC patients (mean [SD] age at diagnosis of NPC 27.8 [15.1] years). Among patients with available data, cognitive, memory and instrumental impairments were most frequent (90% of patients), followed by psychosis (62%), altered behavior (52%) and mood disorders (38%). Psychiatric manifestations were reported before or at neurological disease onset in 41 (76%) patients; organic signs (e.g., hepatosplenomegaly, hearing problems) were reported before psychiatric manifestations in 12 (22%). Substantial delays to diagnosis were observed (5-6 years between psychiatric presentation and NPC diagnosis). Conclusions: NPC should be considered as a possible cause of psychiatric manifestations in patients with an atypical disease course, acute-onset psychosis, treatment failure, and/or certain combinations of psychiatric/neurological/visceral symptoms.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INBORN-ERRORS; ADULT FORM; PSYCHOSIS; DISORDERS; MIGLUSTAT; DIAGNOSIS; COHORT; NEUROPSYCHIATRY; ADOLESCENTS; EXPERIENCE; Niemann-Pick disease type C; psychiatric; psychosis; treatment; systematic review |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 30 Mar 2020 06:54 |
| Last Modified: | 30 Mar 2020 06:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27151 |
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