Cheng, Hung-Wei and Onder, Lucas and Noykovic, Mario and Soneson, Charlotte and Lutge, Mechthild and Pikor, Natalia and Scandella, Elke and Robinson, Mark D. and Miyazaki, Jun-ichi and Tersteegen, Anne and Sorg, Ursula and Pfeffer, Klaus and Ruelicke, Thomas and Hehlgans, Thomas and Ludewig, Burkhard (2019) Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. NATURE COMMUNICATIONS, 10: 1739. ISSN 2041-1723,
Full text not available from this repository. (Request a copy)Abstract
The splenic white pulp is underpinned by poorly characterized stromal cells that demarcate distinct immune cell microenvironments. Here we establish fibroblastic reticular cell (FRC)-specific fate-mapping in mice to define their embryonic origin and differentiation trajectories. Our data show that all reticular cell subsets descend from multipotent progenitors emerging at embryonic day 19.5 from periarterial progenitors. Commitment of FRC progenitors is concluded during the first week of postnatal life through occupation of niches along developing central arterioles. Single cell transcriptomic analysis facilitated deconvolution of FRC differentiation trajectories and indicated that perivascular reticular cells function both as adult lymphoid organizer cells and mural cell progenitors. The lymphotoxin-p receptor-independent sustenance of postnatal progenitor stemness unveils that systemic immune surveillance in the splenic white pulp is governed through subset specification of reticular cells from a multipotent periarterial progenitor cell. In sum, the finding that discrete signaling events in perivascular niches determine the differentiation trajectories of reticular cell networks explains the development of distinct microenvironmental niches in secondary and tertiary lymphoid tissues that are crucial for the induction and regulation of innate and adaptive immune processes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESENCHYMAL STEM-CELLS; MARGINAL ZONE; PRECURSORS; EXPRESSION; MACROPHAGES; PERICYTES; ANTIGEN; STROMA; FORM; INITIATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Apr 2020 06:30 |
| Last Modified: | 14 Apr 2020 06:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27168 |
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