Analysis of a Cahn-Hilliard-Brinkman model for tumour growth with chemotaxis

Ebenbeck, Matthias and Garcke, Harald (2019) Analysis of a Cahn-Hilliard-Brinkman model for tumour growth with chemotaxis. JOURNAL OF DIFFERENTIAL EQUATIONS, 266 (9). pp. 5998-6036. ISSN 0022-0396, 1090-2732

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Abstract

Phase field models recently gained a lot of interest in the context of tumour growth models. Typically Darcy-type flow models are coupled to Cahn-Hilliard equations. However, often Stokes or Brinkman flows are more appropriate flow models. We introduce and mathematically analyse a new Cahn-Hilliard-Brinkman model for tumour growth allowing for chemotaxis. Outflow boundary conditions are considered in order not to influence tumour growth by artificial boundary conditions. Existence of global-in-time weak solutions is shown in a very general setting. (C) 2018 Elsevier Inc. All rights reserved.

Item Type: Article
Uncontrolled Keywords: NONLINEAR SIMULATION; WELL-POSEDNESS; DARCY SYSTEM; VISCOSITY; INVASION; Tumour growth; Cahn-Hilliard equation; Brinkman's law; Chemotaxis; Stokes flow; Outflow conditions
Subjects: 500 Science > 510 Mathematics
Divisions: Mathematics > Prof. Dr. Harald Garcke
Depositing User: Dr. Gernot Deinzer
Date Deposited: 15 Apr 2020 08:22
Last Modified: 15 Apr 2020 08:22
URI: https://pred.uni-regensburg.de/id/eprint/27171

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