Patel, Riyaz S. and Schmidt, Amand F. and Tragante, Vinicius and McCubrey, Raymond O. and Holmes, Michael and Howe, Laurence J. and Direk, Kenan and Akerblom, Axel and Leander, Karin and Virani, Salim S. and Kaminski, Karol A. and Muehlschlegel, Jochen D. and Dube, Marie-Pierre and Allayee, Hooman and Almgren, Peter and Alver, Maris and Baranova, Ekaterina and Behlouli, Hassan and Boeckx, Bram and Braund, Peter S. and Breitling, Lutz P. and Delgado, Graciela and Duarte, Nubia E. and Dufresne, Line and Eriksson, Niclas and Foco, Luisa and Gijsberts, Crystel M. and Gong, Yan and Hartiala, Jaana and Heydarpour, Mahyar and Hubacek, Jaroslav A. and Kleber, Marcus and Kofink, Daniel and Kuukasjarvi, Pekka and Lee, Vei-Vei and Leiherer, Andreas and Lenzini, Petra A. and Levin, Daniel and Lyytikainen, Leo-Pekka and Martinelli, Nicola and Mons, Ute and Nelson, Christopher P. and Nikus, Kjell and Pilbrow, Anna P. and Ploski, Rafal and Sun, Yan and Tanck, Michael W. T. and Tang, W. H. Wilson and Trompet, Stella and van der Laan, Sander W. and van Setten, Jessica and Vilmundarson, Ragnar O. and Anselmi, Chiara Viviani and Vlachopoulou, Efthymia and Boerwinkle, Eric and Briguori, Carlo and Carlquist, John F. and Carruthers, Kathryn F. and Casu, Gavino and Deanfield, John and Deloukas, Panos and Dudbridge, Frank and Fitzpatrick, Natalie and Gigante, Bruna and James, Stefan and Lokki, Marja-Liisa and Lotufo, Paulo A. and Marziliano, Nicola and Mordi, Ify R. and Muhlestein, Joseph B. and Cheh, Chris Newton and Pitha, Jan and Saely, Christoph H. and Samman-Tahhan, Ayman and Sandesara, Pratik B. and Teren, Andrej and Timmis, Adam and Van de Werf, Frans and Wauters, Els and Wilde, Arthur A. M. and Ford, Ian and Stott, David J. and Algra, Ale and Andreassi, Maria G. and Ardissino, Diego and Arsenault, Benoit J. and Ballantyne, Christie M. and Bergmeijer, Thomas O. and Bezzina, Connie R. and Body, Simon C. and Bogaty, Peter and de Borst, Gert J. and Brenner, Hermann and Burkhardt, Ralph and Carpeggiani, Clara and Condorelli, Gianluigi and Cooper-DeHoff, Rhonda M. and Cresci, Sharon and de Faire, Ulf and Doughty, Robert N. and Drexel, Heinz and Engert, James C. and Fox, Keith A. A. and Girelli, Domenico and Hagstrom, Emil and Hazen, Stanley L. and Held, Claes and Hemingway, Harry and Hoefer, Imo E. and Hovingh, G. Kees and Johnson, Julie A. and De Jong, Pim A. and Jukema, J. Wouter and Kaczor, Marcin P. and Kahonen, Mika and Kettner, Jiri and Kiliszek, Marek and Klungel, Olaf H. and Lagerqvist, Bo and Lambrechts, Diether and Laurikka, Jari O. and Lehtimaki, Terho and Lindholm, Daniel and Mahmoodi, Bakhtawar K. and Maitland-van der Zee, Anke H. and McPherson, Ruth and Melander, Olle and Metspalu, Andres and Pepinski, Witold and Olivieri, Oliviero and Opolski, Grzegorz and Palmer, Colin N. and Pasterkamp, Gerard and Pepine, Carl J. and Pereira, Alexandre C. and Note, Louise and Quyyumi, Arshed A. and Richards, A. Mark and Sanak, Marek and Scholz, Markus and Siegbahn, Agneta and Sinisalo, Juha and Smith, J. Gustav and Spertus, John A. and Stewart, Alexandre F. R. and Szczeklik, Wojciech and Szpakowicz, Anna and ten Berg, Jurrien M. and Thanassoulis, George and Thieiy, Joachim and van der Graaf, Yolanda and Visseren, Frank L. J. and Waltenberger, Johannes and Van der Harst, Pim and Tardif, Jean-Claude and Sattar, Naveed and Lang, Chim C. and Pare, Guillaume and Brophy, James M. and Anderson, Jeffrey L. and Maerz, Winfried and Wallentin, Lars and Cameron, Vicky A. and Horne, Benjamin D. and Samani, Nilesh J. and Hingorani, Aroon D. and Asselbergs, Folkert W. (2019) Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events A GENIUS-CHD Study of Individual Participant Data. CIRCULATION-GENOMIC AND PRECISION MEDICINE, 12 (4): e002471. ISSN 2574-8300,
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS: A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103 357 Europeans with established CHD at baseline from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) Consortium (73.1% male, mean age 62.9 years). The primary outcome, subsequent CHD death or myocardial infarction (CHD death/myocardial infarction), occurred in 13 040 of the 93 115 participants with available outcome data. Effect estimates were compared with case/control risk obtained from the CARDIoGRAMplusC4D consortium (Coronary Artery Disease Genome-wide Replication and Meta-analysis [CARDIoGRAM] plus The Coronary Artery Disease [C4D] Genetics) including 47 222 CHD cases and 122 264 controls free of CHD. RESULTS: Meta-analyses revealed no significant association between chromosome 9p21 and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline (GENIUSCHD odds ratio, 1.02; 95% CI, 0.99-1.05). This contrasted with a strong association in CARDIoGRAMPlusC4D odds ratio 1.20; 95% CI, 1.18-1.22; P for interaction < 0.001 compared with the GENIUS-CHD estimate. Similarly, no clear associations were identified for additional subsequent outcomes, including all-cause death, although we found a modest positive association between chromosome 9p21 and subsequent revascularization (odds ratio, 1.07; 95% CI, 1.04-1.09). CONCLUSIONS: In contrast to studies comparing individuals with CHD to disease-free controls, we found no clear association between genetic variation at chromosome 9p21 and risk of subsequent acute CHD events when all individuals had CHD at baseline. However, the association with subsequent revascularization may support the postulated mechanism of chromosome 9p21 for promoting atheroma development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RECURRENT MYOCARDIAL-INFARCTION; RISK; VARIANTS; LOCUS; BIAS; chromosome; genetic; variation; myocardial infarction; risk factor; secondary prevention |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Apr 2020 09:24 |
| Last Modified: | 15 Apr 2020 09:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27211 |
Actions (login required)
 |
View Item |
