Patel, Riyaz S. and Tragante, Vinicius and Schmidt, Amand F. and McCubrey, Raymond O. and Holmes, Michael and Howe, Laurence J. and Direk, Kenan and Akerblom, Axel and Leander, Karin and Virani, Salim S. and Kaminski, Karol A. and Muehlschlegel, Jochen D. and Allayee, Hooman and Almgren, Peter and Alver, Maris and Baranova, Ekaterina and Behloui, Hassan and Boeckx, Bram and Braund, Peter S. and Breitling, Lutz P. and Delgado, Graciela and Duarte, Nubia E. and Dube, Marie-Pierre and Dufresne, Line and Eriksson, Niclas and Foco, Luisa and Scholz, Markus and Gijsberts, Crystel M. and Glinge, Charlotte and Gong, Yan and Hartiala, Jaana and Heydarpour, Mahyar and Hubacek, Jaroslav A. and Kleber, Marcus and Kofink, Daniel and Kotti, Salma and Kuukasjarvi, Pekka and Lee, Vei-Vei and Leiherer, Andreas and Lenzini, Petra A. and Levin, Daniel and Lyytikainen, Leo-Pekka and Martinelli, Nicola and Mons, Ute and Nelson, Christopher P. and Nikus, Kjell and Pilbrow, Anna P. and Ploski, Rafal and Sun, Yan and Tanck, Michael W. T. and Tang, W. H. Wilson and Trompet, Stella and van der Laan, Sander W. and Van Setten, Jessica and Vilmundarson, Ragnar O. and Anselmi, Chiara Viviani and Vlachopoulou, Efthymia and Al Ali, Lawien and Boerwinkle, Eric and Briguori, Carlo and Carlquist, John F. and Carruthers, Kathryn F. and Casu, Gavino and Deanfield, John and Deloukas, Panos and Dudbridge, Frank and Engstrom, Thomas and Fitzpatrick, Natalie and Fox, Kim and Gigante, Bruna and James, Stefan and Lokki, Marja-Liisa and Lotufo, Paulo A. and Marziliano, Nicola and Mordi, Ify R. and Muhlestein, Joseph B. and Newton-Cheh, Christopher and Pitha, Jan and Saely, Christoph H. and Samman-Tahhan, Ayman and Sandesara, Pratik B. and Teren, Andrej and Timmis, Adam and Van de Werf, Frans and Wauters, Els and Wilde, Arthur A. M. and Ford, Ian and Stott, David J. and Algra, Ale and Andreassi, Maria G. and Ardissino, Diego and Arsenault, Benoit J. and Ballantyne, Christie M. and Bergmeijer, Thomas O. and Bezzina, Connie R. and Body, Simon C. and Boersma, Eric H. and Bogaty, Peter and Bots, Michiel L. and Brenner, Hermann and Brugts, Jasper J. and Burkhardt, Ralph and Carpeggiani, Clara and Condorelli, Gianluigi and Cooper-DeHoff, Rhonda M. and Cresci, Sharon and Danchin, Nicolas and de Faire, Ulf and Doughty, Robert N. and Drexel, Heinz and Engert, James C. and Fox, Keith A. A. and Girelli, Domenico and Grobbee, Diederick E. and Hagstrom, Emil and Hazen, Stanley L. and Held, Claes and Hemingway, Harry and Hoefer, Imo E. and Hovingh, G. Kees and Jabbari, Reza and Johnson, Julie A. and Jukema, J. Wouter and Kaczor, Marcin P. and Kahonen, Mika and Kettner, Jiri and Kiliszek, Marek and Klungel, Olaf H. and Lagerqvist, Bo and Lambrechts, Diether and Laurikka, Jari O. and Lehtimaki, Terho and Lindholm, Daniel and Mahmoodi, B. K. and Maitland-van der Zee, Anke H. and McPherson, Ruth and Melander, Olle and Metspalu, Andres and Niemcunowicz-Janica, Anna and Olivieri, Oliviero and Opolski, Grzegorz and Palmer, Colin N. and Pasterkamp, Gerard and Pepine, Carl J. and Pereira, Alexandre C. and Pilote, Louise and Quyyumi, Arshed A. and Richards, A. Mark and Sanak, Marek and Siegbahn, Agneta and Simon, Tabassome and Sinisalo, Juha and Smith, J. Gustav and Spertus, John A. and Stender, Steen and Stewart, Alexandre F. R. and Szczeklik, Wojciech and Szpakowicz, Anna and Tardif, Jean-Claude and ten Berg, Jurrien M. and Tfelt-Hansen, Jacob and Thanassoulis, George and Thiery, Joachim and Torp-Pedersen, Christian and van der Graaf, Yolanda and Visseren, Frank L. J. and Waltenberger, Johannes and Weeke, Peter E. and Van der Harst, Pim and Lang, Chim C. and Sattar, Naveed and Cameron, Vicky A. and Anderson, Jeffrey L. and Brophy, James M. and Pare, Guillaume and Horne, Benjamin D. and Marz, Winfried and Wallentin, Lars and Samani, Nilesh J. and Hingorani, Aroon D. and Asselbergs, Folkert W. (2019) Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium. CIRCULATION-GENOMIC AND PRECISION MEDICINE, 12 (4): e002470. ISSN , 2574-0954
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BODY-MASS INDEX; CARDIOVASCULAR MORTALITY; MYOCARDIAL-INFARCTION; ARTERY-DISEASE; PUBLIC-HEALTH; BIOBANK; coronary artery disease; genetics; myocardial infarction; prognosis; secondary prevention |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Apr 2020 09:43 |
| Last Modified: | 15 Apr 2020 09:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27212 |
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