Zhan, Tianzuo and Sollors, Janina and Steinebrunner, Niels and Schlitt, Hans Juergen and Stroszczynski, Christian and Weiss, Karl Heinz and Ebert, Matthias P. and Teufel, Andreas (2019) Pharmacological treatment of hepatocellular carcinoma with cavoatrial tumor thrombus - case series and literature review. ZEITSCHRIFT FUR GASTROENTEROLOGIE, 57 (4). pp. 501-507. ISSN 0044-2771, 1439-7803
Full text not available from this repository. (Request a copy)Abstract
Hepatocellular carcinomas (HCC) that extend into the vena cave and the right atrium have a poor prognosis. Surgical approaches including partial hepatectomy and thrombectomy are the most frequently reported treatment options. However, most patients with advanced HCC are not eligible for complex surgical interventions due to reduced liver function, comorbidities, and metastases. At the same time, systemic treatment options of HCC have expanded in recent years. Here, we report 3 cases of patients with advanced HCC who developed a cavoatrial tumor thrombus (CATT) after initial surgical or interventional therapy. The patients were consequently treated with sorafenib or nivolumab. In all cases, the tumor responded to systemic treatment with disease stabilization or partial regression. Overall survival after diagnosis of CATT was 3 and 17 months for sorafenib and 7+ months for nivolumab. Compared to survival rates of alternative treatment options, systemic therapies demonstrated comparable outcomes. In summary, pharmacotherapy is an efficient and well worth option to treat patients with HCC and CATT and should be an integral part of a multimodal therapy concept.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFERIOR VENA-CAVA; RIGHT ATRIUM; CARDIOPULMONARY BYPASS; PULMONARY-EMBOLISM; SURGICAL-TREATMENT; PHASE-II; LIVER; SORAFENIB; THROMBECTOMY; THALIDOMIDE; liver; hepatitis C; hepatitis B; HCC; immunotherapy; liver cirrhosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 27 Mar 2020 11:20 |
| Last Modified: | 27 Mar 2020 11:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27232 |
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