Karrer, S. and Aschoff, R. A. G. and Dominicus, R. and Kraehn-Senftleben, G. and Gauglitz, G. G. and Zarzour, A. and Kerrouche, N. and Chavda, R. and Szeimies, R. -M. (2019) Methyl aminolevulinate daylight photodynamic therapy applied at home for non-hyperkeratotic actinic keratosis of the face or scalp: an open, interventional study conducted in Germany. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 33 (4). pp. 661-666. ISSN 0926-9959, 1468-3083
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Background The efficacy and safety of methyl aminolevulinate daylight photodynamic therapy (MAL DL-PDT) for actinic keratosis (AK) treatment has previously been demonstrated in several studies. Objective To evaluate patient-reported outcomes, effectiveness and tolerability of patient self-applied MAL DL-PDT. Patients and methods An open study was conducted in Germany in patients with thin or non-hyperkeratotic and non-pigmented AK. At baseline, the investigator delimited the target anatomical area and skin preparation was discretionary. On day 1, the patient performed MAL DL-PDT at home, in accordance with instructions (after applying sunscreen and skin preparation by abrasive pad). Patient questionnaires were completed on day 1 and 3 months post-treatment. Effectiveness was assessed by investigator at 3 months. Pain and adverse events (AE) were recorded. Results Patients (n = 50) were mostly elderly (mean age: 73.4 years) men (86%). After treatment on day 1, 94% of patients were overall satisfied or very satisfied with the treatment and 98% found the instructions convenient. At 3 months, most patients were satisfied or very satisfied with treatment effectiveness (88%) and aspect of their skin (80%). At 3 months, 62% of overall lesions were completely clear. The main related AEs were mild and expected (erythema, procedural pain and skin burning sensation). Conclusions Patient self-application of MAL DL-PDT resulted in high levels of patient satisfaction, effectiveness and tolerability.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EUROPEAN DERMATOLOGY FORUM; CRYOTHERAPY; GUIDELINES; PATIENT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Apr 2020 06:03 |
| Last Modified: | 20 Apr 2020 06:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27286 |
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