Roensch, Henriette and Apfelbacher, Christian and Brans, Richard and Matterne, Uwe and Molin, Sonja and Ofenloch, Robert and Oosterhaven, Jart A. F. and Schuttelaar, Marie L. A. and Weisshaar, Elke and Yew, Yik Weng and Bauer, Andrea (2019) Which outcomes have been measured in hand eczema trials? A systematic review. CONTACT DERMATITIS, 80 (4). pp. 201-207. ISSN 0105-1873, 1600-0536
Full text not available from this repository. (Request a copy)Abstract
The considerable heterogeneity of outcomes and measurement instruments in hand eczema trials substantially limits the evidence synthesis concerning therapeutic and preventive interventions. Therefore, the Hand Eczema Core Outcome Set (HECOS) initiative is developing a core outcome set for future trials. The first objective was to identify outcomes that were measured in previous trials, to group them in domains, and to identify their measurement instruments. We conducted a systematic review of controlled and randomized controlled hand eczema trials published since 2000. Sixty-one eligible studies were identified. Each assessed one or more of 47 outcomes in the "skin" domain. Eighteen trials (30%) additionally focused on preventive behaviour in risk occupations. Quality of life was measured in 13 studies (21%). Thirty-two distinct named instruments were applied, but 223 measurements (62%) were conducted with unnamed instruments. Only 32 studies (52%) defined a primary outcome. Twenty-nine trials (48%) provided some information on adverse events, but none gave any references concerning relevant methods. Our review confirms the need to harmonize outcome measurements in hand eczema trials. The findings form the basis for a consensus process to generate a core outcome set to improve the explanatory power and comparability of future hand eczema studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FOLLOW-UP; POPULATION; EPIDEMIOLOGY; LIFE; core outcome set; CS-COUSIN; hand dermatitis; outcome measurement instruments |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 27 Mar 2020 11:13 |
| Last Modified: | 27 Mar 2020 11:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27295 |
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