Unterrainer, Marcus and Fleischmann, D. F. and Diekmann, C. and Vomacka, L. and Lindner, S. and Vettermann, F. and Brendel, M. and Wenter, V. and Ertl-Wagner, B. and Herms, J. and Wetzel, C. and Rupprecht, R. and Tonn, J. C. and Belka, C. and Bartenstein, P. and Niyazi, M. and Albert, Nathalie L. (2019) Comparison of F-18-GE-180 and dynamic F-18-FET PET in high grade glioma: a double-tracer pilot study. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 46 (3). pp. 580-590. ISSN 1619-7070, 1619-7089
Full text not available from this repository. (Request a copy)Abstract
BackgroundPET represents a valuable tool for glioma imaging. In addition to amino acid tracers such as F-18-FET, PET targeting the 18-kDa mitochondrial translocator-protein (TSPO) is of high interest for high-grade glioma (HGG) imaging due to its upregulation in HGG cells. F-18-GE-180, a novel TSPO ligand, has shown a high target-to-background contrast in HGG. Therefore, we intra-individually compared its uptake characteristics to dynamic F-18-FET PET and contrast-enhanced MRI in patients with HGG.MethodsTwenty HGG patients (nine IDH-wildtype, 11 IDH-mutant) at initial diagnosis (n=8) or recurrence (n=12) were consecutively included and underwent F-18-GE-180 PET, dynamic F-18-FET PET, and MRI. The maximal tumour-to-background ratios (TBRmax) and biological tumour volumes (BTV) were evaluated in F-18-GE-180 and F-18-FET PET. Dynamic F-18-FET PET analysis included the evaluation of minimal time-to-peak (TTPmin). In MRI, the volume of contrast-enhancement was delineated (VOLCE). Volumes were spatially correlated using the SOrensen-Dice coefficient.ResultsThe median TBRmax tended to be higher in F-18-GE-180 PET compared to F-18-FET PET [4.58 (2.33-8.95) vs 3.89 (1.56-7.15); p=0.062] in the overall group. In subgroup analyses, IDH-wildtype gliomas showed a significantly higher median TBRmax in F-18-GE-180 PET compared to F-18-FET PET [5.45 (2.56-8.95) vs 4.06 (1.56-4.48); p=0.008]; by contrast, no significant difference was observed in IDH-mutant gliomas [3.97 (2.33-6.81) vs 3.79 (2.01-7.15) p=1.000]. Only 5/20 cases showed higher TBRmax in F-18-FET PET compared to F-18-GE-180 PET, all of them being IDH-mutant gliomas. No parameter in F-18-GE-180 PET correlated with TTPmin (p>0.05 each). There was a tendency towards higher median BTVGE-180 [32.1 (0.4-236.0) ml] compared to BTVFET [19.3 (0.7-150.2) ml; p=0.062] with a moderate spatial overlap [median SOrensen-Dice coefficient 0.55 (0.07-0.85)]. In MRI, median VOLCE [9.7 (0.1-72.5) ml] was significantly smaller than both BTVFET and BTVGE180 (p<0.001 each), leading to a poor spatial correlation with BTVGE-180 [0.29 (0.01-0.48)] and BTVFET [0.38 (0.01-0.68)].ConclusionPET with F-18-GE-180 and F-18-FET provides differing imaging information in HGG dependent on the IDH-mutational status, with diverging spatial overlap and vast exceedance of contrast-enhancement in MRI. Combined PET imaging might reveal new insights regarding non-invasive characterization of tumour heterogeneity and might influence patients' management.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSITRON-EMISSION-TOMOGRAPHY; TRANSLOCATOR PROTEIN; TSPO-PET; RESPONSE ASSESSMENT; BINDING; EXPRESSION; LIGAND; MODEL; BRAIN; NEUROINFLAMMATION; F-18-GE-180; TSPO; F-18-FET; Amino acid; MRI; High-grade glioma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Apr 2020 10:19 |
| Last Modified: | 21 Apr 2020 10:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27506 |
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