Kramm, Kevin and Engel, Christoph and Grohmann, Dina (2019) Transcription initiation factor TBP: old friend new questions. BIOCHEMICAL SOCIETY TRANSACTIONS, 47 (1). pp. 411-423. ISSN 0300-5127, 1470-8752
Full text not available from this repository. (Request a copy)Abstract
In all domains of life, the regulation of transcription by DNA-dependent RNA polymerases (RNAPs) is achieved at the level of initiation to a large extent. Whereas bacterial promoters are recognized by a sigma-factor bound to the RNAP, a complex set of transcription factors that recognize specific promoter elements is employed by archaeal and eukaryotic RNAPs. These initiation factors are of particular interest since the regulation of transcription critically relies on initiation rates and thus formation of pre-initiation complexes. The most conserved initiation factor is the TATA-binding protein (TBP), which is of crucial importance for all archaeal-eukaryotic transcription initiation complexes and the only factor required to achieve full rates of initiation in all three eukaryotic and the archaeal transcription systems. Recent structural, biochemical and genome-wide mapping data that focused on the archaeal and specialized RNAP I and III transcription system showed that the involvement and functional importance of TBP is divergent from the canonical role TBP plays in RNAP II transcription. Here, we review the role of TBP in the different transcription systems including a TBP-centric discussion of archaeal and eukaryotic initiation complexes. We furthermore highlight questions concerning the function of TBP that arise from these findings.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RNA-POLYMERASE-I; TATA-BINDING-PROTEIN; UPSTREAM ACTIVATION FACTOR; III TRANSCRIPTION; CRYSTAL-STRUCTURE; YEAST TATA; BASAL TRANSCRIPTION; STRUCTURAL BASIS; RIBOSOMAL DNA; MINOR-GROOVE; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 27 Mar 2020 06:52 |
| Last Modified: | 27 Mar 2020 06:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27512 |
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