Wagener, Rabea and Seufert, Julian and Raimondi, Francesco and Bens, Susanne and Kleinheinz, Kortine and Nagel, Inga and Altmueller, Janine and Thiele, Holger and Huebschmann, Daniel and Kohler, Christian W. and Nuernberg, Peter and Au-Yeung, Rex and Burkhardt, Birgit and Horn, Heike and Leoncini, Lorenzo and Jaffe, Elaine S. and Ott, German and Rymkiewicz, Grzegorz and Schlesner, Matthias and Russell, Robert B. and Klapper, Wolfram and Siebert, Reiner (2019) The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma. BLOOD, 133 (9). pp. 962-966. ISSN 0006-4971, 1528-0020
Full text not available from this repository. (Request a copy)Abstract
The new recently described provisional lymphoma category Burkitt-like lymphoma with 11q aberration comprises cases similar to Burkitt lymphoma (BL) on morphological, immunophenotypic and gene-expression levels but lacking the IG-MYC translocation. They are characterized by a peculiar imbalance pattern on chromosome 11, but the landscape of mutations is not yet described. Thus, we investigated 15 MYC-negative Burkitt-like lymphoma with 11q aberration (mnBLL, 11q,) cases by copy-number analysis and whole-exome sequencing. We refined the regions of 11q imbalance and identified the INO80 complex-associated gene NFRKB as a positional candidate in 11q24.3. Next to recurrent gains in 12q13.11-q24.32 and 7q34-qter as well as losses in 13q32.3-q34, we identified 47 genes recurrently affected by protein-changing mutations (each >= 3 of 15 cases). Strikingly, we did not detect recurrent mutations in genes of the ID3-TCF3 axis or the SWI/SNF complex that are frequently altered in BL, or in genes frequently mutated in germinal center-derived B-cell lymphomas like KMT2D or CREBBP. An exception is GNA13, which was mutated in 7 of 15 cases. We conclude that the genomic landscape of mnBLL, 11q, differs from that of BL both at the chromosomal and mutational levels. Our findings implicate that mnBLL, 11q, is a lymphoma category distinct from BL at the molecular level.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | B-CELL LYMPHOMAS; HETEROGENEITY; GENOME; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Apr 2020 05:45 |
| Last Modified: | 17 Apr 2020 05:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27513 |
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