Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective

ten Brinke, Anja and Martinez-Llordella, Marc and Cools, Nathalie and Hilkens, Catharien M. U. and van Ham, S. Marieke and Sawitzki, Birgit and Geissler, Edward K. and Lombardi, Giovanna and Trzonkowski, Piotr and Martinez-Caceres, Eva (2019) Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective. FRONTIERS IN IMMUNOLOGY, 10: 181. ISSN 1664-3224

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Abstract

Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.

Item Type: Article
Uncontrolled Keywords: REGULATORY T-CELLS; TOLEROGENIC DENDRITIC CELLS; MULTIPLE-SCLEROSIS; ADOPTIVE TRANSFER; FLOW-CYTOMETRY; AUTOIMMUNE-DISEASES; ALLOGRAFT SURVIVAL; IN-VIVO; TRANSPLANTATION; CD4(+); tolerance; dendritic cells; regulatory T cells; autoimmunity; transplantation; cell therapy; clinic; immunomonitoring
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Chirurgie
Depositing User: Petra Gürster
Date Deposited: 27 Mar 2020 06:48
Last Modified: 27 Mar 2020 06:48
URI: https://pred.uni-regensburg.de/id/eprint/27525

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