Eggemann, Holm and Bernreiter, Anna-Lena and Reinisch, Mattea and Loibl, Sibylle and Taran, Florin-Andrei and Costa, Serban-Dan and Ignatov, Atanas (2019) Tamoxifen treatment for male breast cancer and risk of thromboembolism: prospective cohort analysis. BRITISH JOURNAL OF CANCER, 120 (3). pp. 301-305. ISSN 0007-0920, 1532-1827
Full text not available from this repository. (Request a copy)Abstract
PURPOSE: Thromboembolism is a common adverse event in women treated with tamoxifen (TAM) for breast cancer. The risk in male breast cancer patients is poorly investigated. We aimed to examine the risk of thrombotic events after TAM in male breast cancer patients. PATIENTS AND METHODS: In this prospective cohort study, 448 patients treated between May 2009 and July 2017 for male breast cancer (BC) were assessed for eligibility. Patients with follow-up shorter than 6 months were excluded. The cumulative risk of thromboembolism was evaluated. RESULTS: The median follow-up was 47 months (range 6-101 months) with a median age of 69.4 years (range 27-89 years). Oestrogen receptor and progesterone receptor expression levels were observed in 98.3 and 94.9% of cases, respectively. During the follow-up period, thrombotic events were documented in 21 (11.9%) of 177 patients receiving TAM and in 1 (2.5%) of 41 patients who did not receive tamoxifen. The estimated incidence was 51.9 per 1000 person-years and 21.5 per 1000 person-years, respectively. Notably, the highest risk was identified in the first 18 months, where 81% of the observed thrombotic events occurred. Patients aged older than 71 years had a significantly increased risk of thrombotic event under TAM treatment than their younger counterparts (p = 0.033). History of thrombotic event, cardiovascular and liver disease, as well as additional adjuvant treatment were not associated with increased thrombotic risk. CONCLUSION: The risk of thrombotic event in men treated with TAM for breast cancer is markedly increased in the first 18 months of treatment, and should be considered during treatment decisions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VENOUS THROMBOSIS; THERAPY; DISEASE; WOMEN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Apr 2020 06:03 |
| Last Modified: | 22 Apr 2020 06:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27564 |
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