Ignatov, Tanja and Claus, Maria and Nass, Norbert and Haybaeck, Johannes and Seifert, Bernd and Kalinski, Thomas and Ortmann, Olaf and Ignatov, Atanas (2019) G-protein-coupled estrogen receptor GPER-1 expression in hormone receptor-positive breast cancer is associated with poor benefit of tamoxifen. BREAST CANCER RESEARCH AND TREATMENT, 174 (1). pp. 121-127. ISSN 0167-6806, 1573-7217
Full text not available from this repository. (Request a copy)Abstract
BackgroundThe role of G-protein-coupled estrogen receptor 1 (GPER-1) in the development of tamoxifen resistance in breast cancer is a highly controversial issue. The aim of this study was to determine the expression of GPER-1 in the clinical routine under conditions of endocrine treatment.Patients and methodsGPER-1 expression was analyzed in 442 patients with primary invasive breast cancer. GPER-1 score of >3 was determined as positive. Expression data were correlated with clinical and pathological characteristics and patient survival.ResultsGPER-1 expression was observed in 352 (80.9%) cases, and positively correlated with estrogen and progesterone receptor status (p=0.0001). GPER-1 positivity was associated with an increased grade of differentiation (p=0.0001) and with a low level of Ki-67 expression (p=0.0001). High GPER-1 expression was associated with a decreased level upon systemic treatment (p=0.011). In the whole cohort, GPER-1 expression was associated with prolonged disease-free survival (DFS). DFS between tamoxifen- and aromatase inhibitor-treated GPER-1-positive patients was similar (p=0.090). Notably, after matching the analysis for the most important prognostic factors, DFS for tamoxifen-treated GPER-1-positive patients was 69.1%, which is a percentage that is significantly lower compared to DFS for GPER-1-positive patients treated with aromatase inhibitors (92.7%) (p=0.005).ConclusionGPER-1 expression is a favorable prognostic factor in breast cancer patients. Its predictive role for poor benefit form tamoxifen treatment should be investigated in further studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-SUPPRESSOR; PROLIFERATION; ACTIVATION; MEMBRANE; GPER-1; GPR30; Breast cancer; Tamoxifen resistance; Estrogen |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Apr 2020 07:06 |
| Last Modified: | 22 Apr 2020 07:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27592 |
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