Grijalvo, Santiago and Puras, Gustavo and Zarate, Jon and Sainz-Ramos, Myriam and Qtaish, Nuseibah A. L. and Lopez, Tania and Mashal, Mohamed and Attia, Noha and Diaz Diaz, David and Pons, Ramon and Fernandez, Eduardo and Luis Pedraz, Jose and Eritja, Ramon (2019) Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery. PHARMACEUTICS, 11 (2): 50. ISSN 1999-4923
Full text not available from this repository. (Request a copy)Abstract
Cationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their structural similarities to liposomes. Cationic niosomes are usually obtained from the self-assembly of non-ionic surfactant molecules. This process can be governed not only by the nature of such surfactants but also by others factors like the presence of additives, formulation preparation and properties of the encapsulated hydrophobic or hydrophilic molecules. This review is aimed at providing recent information for using cationic niosomes for gene delivery purposes with particular emphasis on improving the transportation of antisense oligonucleotides (ASOs), small interference RNAs (siRNAs), aptamers and plasmids (pDNA).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NONIONIC SURFACTANT VESICLES; ANTISENSE OLIGONUCLEOTIDES; DRUG-DELIVERY; LIPID NANOPARTICLES; SIRNA DELIVERY; HELPER LIPIDS; BREAST-CANCER; TRANSFECTION EFFICIENCY; MULTIDRUG-RESISTANCE; THERAPEUTIC DELIVERY; antisense oligonucleotides; aptamers; cationic lipids; cationic niosomes; gene delivery; plasmids; small interference RNA; therapy |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 Mar 2020 11:12 |
| Last Modified: | 26 Mar 2020 11:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27602 |
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