Nemeckova-Makrlikova, Anna and Matysik, Frank-Michael and Navratil, Tomas and Barek, Jiri and Vyskocil, Vlastimil (2019) Determination of three Tumor Biomarkers (Homovanillic Acid, Vanillylmandelic Acid, and 5-Hydroxyindole-3-Acetic Acid) Using Flow Injection Analysis with Amperometric Detection. ELECTROANALYSIS, 31 (2). pp. 303-308. ISSN 1040-0397, 1521-4109
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Flow injection analysis with amperometric detection (FIA-AD) at screen-printed carbon electrodes (SPCEs) in optimum medium of Britton-Robinson buffer (0.04molL(-1), pH2.0) was used for the determination of three tumor biomarkers (homovanillic acid (HVA), vanillylmandelic acid (VMA), and 5-hydroxyindole-3-acetic acid (5-HIAA)). Dependences of the peak current on the concentration of biomarkers were linear in the whole tested concentration range from 0.05 to 100molL(-1), with limits of detection (LODs) of 0.065molL(-1) for HVA, 0.053molL(-1) for VMA, and 0.033molL(-1) for 5-HIAA (calculated from peak heights), and 0.024molL(-1) for HVA, 0.020molL(-1) for VMA, and 0.012molL(-1) for 5-HIAA (calculated from peak areas), respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERFORMANCE LIQUID-CHROMATOGRAPHY; 5-HYDROXY-3-INDOLEACETIC ACID; VOLTAMMETRIC DETERMINATION; CATECHOLAMINE METABOLITES; ELECTROCHEMICAL METHODS; ACETIC-ACID; URINE; ASSAY; NEUROBLASTOMA; DOPAMINE; Screen-printed carbon electrodes; Flow injection analysis; Amperometric detection; Homovanillic acid; Vanillylmandelic acid; 5-Hydroxyindole-3-acetic acid |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Instrumentelle Analytik (Prof. Frank-Michael Matysik) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 May 2022 06:46 |
| Last Modified: | 25 May 2022 06:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27625 |
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